The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung
about
Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL)Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activationNovel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch IILocal activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizesRegulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by RasRASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancerRASSF tumor suppressor gene family: biological functions and regulationCpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancerThe growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathwayRASSF6 is a novel member of the RASSF family of tumor suppressorsRas oncogenes: split personalitiesTargeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerNORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation.The growth and tumor suppressors NORE1A and RASSF1A are targets for calpain-mediated proteolysis.The Ras-association domain family (RASSF) members and their role in human tumourigenesis.Epigenetic inactivation of the NORE1 gene correlates with malignant progression of colorectal tumorslgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK.Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers.RIN1 is a breast tumor suppressor gene.Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.The RASSF1A tumor suppressor activates Bax via MOAP-1.Death pathways triggered by activated Ras in cancer cellsRASSF1A: Not a prototypical Ras effector.Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis.Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathwaysRas Regulates Rb via NORE1A.Ras and rheb signaling in survival and cell deathA common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes.Aberrant Promoter Hypermethylation of RASSF Family Members in Merkel Cell Carcinoma.Colorectal cancer and RASSF family--a special emphasis on RASSF1A.Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanismRASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion.Ras signaling through RASSF proteins.The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.Functional importance of RASSF1A microtubule localization and polymorphisms.Dynamics of RASSF1A/MOAP-1 association with death receptors.Gene expression profile associated with oncogenic ras-induced senescence, cell death, and transforming properties in human cells.Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma.
P2860
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P2860
The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung
description
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im April 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 13 June 2003)
@en
vedecký článok (publikovaný 2003/06/13)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/06/13)
@nl
наукова стаття, опублікована в червні 2003
@uk
name
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@ast
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@en
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@nl
type
label
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@ast
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@en
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@nl
prefLabel
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@ast
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@en
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@nl
P2093
P2860
P3181
P356
P1476
The pro-apoptotic Ras effector ...... d tumor suppressor in the lung
@en
P2093
Chad A Ellis
Geoffrey J Clark
Michele D Vos
Teresa Vallecorsa
P2860
P304
21938-21943
P3181
P356
10.1074/JBC.M211019200
P407
P50
P577
2003-04-03T00:00:00Z