Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2 - Wikidata - wikimedia - TriplyDB

Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2

Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2

http://www.wikidata.org/entity/Q28196584

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GPVI and integrin alphaIIb beta3 signaling in platelets Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion PI 3-kinase p110beta: a new target for antithrombotic therapy Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading.Integrin-mediated membrane blebbing is dependent on sodium-proton exchanger 1 and sodium-calcium exchanger 1 activity.Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1 Using microcontact printing of fibrinogen to control surface-induced platelet adhesion and activation.Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.Laminin interactions with head and neck cancer cells under low fluid shear conditions lead to integrin activation and binding.Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation.Future innovations in anti-platelet therapies.Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation.A guide to murine platelet structure, function, assays, and genetic alterations.Platelet integrins and immunoreceptors.Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets Microfluidic devices for studies of shear-dependent platelet adhesion.Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.Platelet signaling-a primer.Regulation of Pannexin-1 channel activity.Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.Involvement of Src kinases and PLCgamma2 in clot retraction.Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites.Key role of integrin α(IIb)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation.Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion.Membrane targeting and coupling of NHE1-integrinalphaIIbbeta3-NCX1 by lipid rafts following integrin-ligand interactions trigger Ca2+ oscillations.External calcium facilitates signalling, contractile and secretory mechanisms induced after activation of platelets by collagen.Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.Platelet factor XIII and calpain negatively regulate integrin alphaIIbbeta3 adhesive function and thrombus growth.SLP-76 stimulates PLC gamma 2 Immobilized fibrinogen activates human platelets through glycoprotein VI.Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

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P2860

Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2

http://www.wikidata.org/entity/Q28196584

description

2003 nî lūn-bûn

@nan

2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

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Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

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Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

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Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

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Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

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Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

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Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

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Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

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Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

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P1433

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P1433

Journal of Biological Chemistry

P1476

Integrin alpha IIb beta 3-depe ...... ent of phospholipase C gamma 2

@en

P2093

Cindy L Yap

http://www.w3.org/2001/XMLSchema#string

Isaac Goncalves

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Sascha C Hughan

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Shaun P Jackson

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Yuping Yuan

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P2860

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor

Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets

Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation

A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1

Ragged spiking of free calcium in ADP-stimulated human platelets: regulation of puff-like calcium signals in vitro and ex vivo

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

Plasma fibronectin promotes thrombus growth and stability in injured arterioles.

LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

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34812-22

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scholarly article

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10.1074/JBC.M306504200

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P407

P433

37

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P478

278

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P50

Simone M Schoenwaelder

P577

2003-09-12T00:00:00Z

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P698

12832405

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