Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading.
about
Microenvironmental geometry guides platelet adhesion and spreading: a quantitative analysis at the single cell levelThree-Dimensional Environment Sustains Hematopoietic Stem Cell Differentiation into Platelet-Producing MegakaryocytesLysine acetyltransfer supports platelet function.Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.Deposition of fibrinogen on the surface of in vitro thrombi prevents platelet adhesionGene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation.The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activationBinding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells.Using microcontact printing of fibrinogen to control surface-induced platelet adhesion and activation.Differential dynamics of platelet contact and spreading.RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in PlateletsFunctional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse PlateletsThe role of fibrinogen spacing and patch size on platelet adhesion under flow.Elevating local concentrations of GPIIb-IIIa antagonists counteracts platelet thrombus stability.Platelet function and Isoprostane biology. Should isoprostanes be the newest member of the orphan-ligand family?How Cells feel their environment: a focus on early dynamic events.Integrin αIIbβ3 outside-in signaling.Origin of the nonadhesive properties of fibrinogen matrices probed by force spectroscopy.Mesenchymal stem cells exploit extracellular matrix as mechanotransducer.Control of integrin alphaIIb beta3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates.ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.Single-platelet nanomechanics measured by high-throughput cytometry.An optical method to quantify the density of ligands for cell adhesion receptors in three-dimensional matrices.Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation.Morphometric analysis of spread platelets identifies integrin αIIbβ3-specific contractile phenotype.Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice.Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals
P2860
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P2860
Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading.
description
2007 nî lūn-bûn
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2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Ligand density dramatically af ...... telet signaling and spreading.
@ast
Ligand density dramatically af ...... telet signaling and spreading.
@en
type
label
Ligand density dramatically af ...... telet signaling and spreading.
@ast
Ligand density dramatically af ...... telet signaling and spreading.
@en
prefLabel
Ligand density dramatically af ...... telet signaling and spreading.
@ast
Ligand density dramatically af ...... telet signaling and spreading.
@en
P2860
P1433
P1476
Ligand density dramatically af ...... telet signaling and spreading.
@en
P2093
Barry S Coller
Markéta Jirousková
P2860
P304
P356
10.1182/BLOOD-2006-10-054015
P407
P577
2007-03-01T00:00:00Z