Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis
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DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFFEvolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathwaySoluble receptor (DcR3) and cellular inhibitor of apoptosis-2 (cIAP-2) protect human cytotrophoblast cells against LIGHT-mediated apoptosisDifferential expression of LIGHT and its receptors in human placental villi and amniochorion membranesMechanisms regulating expression of the tumor necrosis factor-related light gene. Role of calcium-signaling pathway in the transcriptional controlHVEM signalling promotes colitisExcess LIGHT contributes to placental impairment, increased secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia.Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability.Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.Cloning, expression, and characterization of TNFSF14 (LIGHT) gene in mefugu, Takifugu obscurus.TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14)CD161 DEFINES EFFECTOR T CELLS THAT EXPRESS LIGHT AND RESPOND TO TL1A-DR3 SIGNALING.Lymphotoxin and LIGHT signaling pathways and target genes.The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulationTumor necrosis factor family members and inflammatory bowel disease.Immunoregulation by tumor necrosis factor superfamily member LIGHTProinflammatory and prothrombotic effects on human vascular endothelial cells of immune-cell-derived LIGHT.Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival.The canonical and unconventional ligands of the herpesvirus entry mediatorTherapeutic blockade of LIGHT interaction with herpesvirus entry mediator and lymphotoxin β receptor attenuates in vivo cytotoxic allogeneic responsesTargeting lymphocyte activation through the lymphotoxin and LIGHT pathwaysImmunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells.Transglutaminase is a Critical Link Between Inflammation and Hypertension.LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms.Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partnersHVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation.Changes of the cytokine profile in inflammatory bowel diseases.LIGHT/HVEM/LTβR interaction as a target for the modulation of the allogeneic immune response in transplantation.Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis.Trimerization of murine TNF ligand family member LIGHT increases the cytotoxic activity against the FM3A mammary carcinoma cell line.Neutralization of LIGHT ameliorates acute dextran sodium sulphate-induced intestinal inflammation.Turning on LIGHT.The tumor necrosis factor family member TNFSF14 (LIGHT) is required for resolution of intestinal inflammation in mice.Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.LIGHT is dispensable for CD4+ and CD8+ T cell and antibody responses to influenza A virus in mice.Associations between HVEM/LIGHT/BTLA/CD160 polymorphisms and the occurrence of antibody-mediate rejection in renal transplant recipients.
P2860
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P2860
Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis
description
2001 nî lūn-bûn
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2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Genomic characterization of LI ...... ernate splicing or proteolysis
@ast
Genomic characterization of LI ...... ernate splicing or proteolysis
@en
Genomic characterization of LI ...... ernate splicing or proteolysis
@nl
type
label
Genomic characterization of LI ...... ernate splicing or proteolysis
@ast
Genomic characterization of LI ...... ernate splicing or proteolysis
@en
Genomic characterization of LI ...... ernate splicing or proteolysis
@nl
prefLabel
Genomic characterization of LI ...... ernate splicing or proteolysis
@ast
Genomic characterization of LI ...... ernate splicing or proteolysis
@en
Genomic characterization of LI ...... ernate splicing or proteolysis
@nl
P2093
P3181
P1476
Genomic characterization of LI ...... ernate splicing or proteolysis
@en
P2093
K D Butrovich
P Houshmand
S W Granger
W R Edwards
P304
P3181
P356
10.4049/JIMMUNOL.167.9.5122
P407
P577
2001-11-01T00:00:00Z