Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer - Wikidata - wikimedia - TriplyDB

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

http://www.wikidata.org/entity/Q28203143

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Acetylation-dependent regulation of Skp2 function Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells C-terminal phosphorylation controls the stability and function of p27kip1 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1 Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor PHLiPPing the switch on Akt and protein kinase C signaling RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.Knockin of mutant PIK3CA activates multiple oncogenic pathways AKT/PKB signaling: navigating downstream Pten dose dictates cancer progression in the prostate Transforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor protein p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosis Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer Structure of HER receptors and intracellular localisation of downstream effector elements gives insight into mechanism of tumour growth promotion Autophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast Cancer Nodal signaling promotes a tumorigenic phenotype in human breast cancer Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival Tumor suppressor ARF inhibits HER-2/neu-mediated oncogenic growth p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure XB130: A novel adaptor protein in cancer signal transduction Tumor suppressors and cell-cycle proteins in lung cancer CDK4 is an essential insulin effector in adipocytes Activation of the insulin-like growth factor-1 receptor alters p27 regulation by the epidermal growth factor receptor in oral squamous carcinoma cells Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.Inhibitory effect of ubiquitin-proteasome pathway on proliferation of esophageal carcinoma cells.p27Kip1 localization depends on the tumor suppressor protein tuberin.Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts.Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation.Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693.Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells.Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth.Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth.Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

http://www.wikidata.org/entity/Q28203143

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2002 nî lūn-bûn

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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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Cytoplasmic relocalization and ...... osphorylation in breast cancer

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Cytoplasmic relocalization and ...... osphorylation in breast cancer

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Cytoplasmic relocalization and ...... osphorylation in breast cancer

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Nature Medicine

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Cytoplasmic relocalization and ...... osphorylation in breast cancer

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Alfonso Bellacosa

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Amelia D'Alessio

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Daniela Califano

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Floriana Vinci

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Gennaro Chiappetta

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Giuseppe Viglietto

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Maria Letizia Motti

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Massimo Santoro

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Paola Bruni

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Philip Tsichlis

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Direct control of the Forkhead transcription factor AFX by protein kinase B

The Hallmarks of Cancer

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

p16(MTS-1/CDKN2/INK4a) in cancer progression

Regulation of cell death protease caspase-9 by phosphorylation

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