Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction - Wikidata - wikimedia - TriplyDB

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

http://www.wikidata.org/entity/Q24602385

about

Acetylation-dependent regulation of Skp2 function A comparison between Skp2 and FOXO1 for their cytoplasmic localization by Akt1 The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis Skp2: a novel potential therapeutic target for prostate cancer DAB2IP in cancer Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis Posttranslational regulation of Akt in human cancer A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma.AKT signaling mediates IGF-I survival actions on otic neural progenitors.The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration The Arabidopsis cell cycle F-box protein SKP2A binds to auxin.Nuclear translocation of Skp2 facilitates its destruction in response to TGFβ signaling.Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.Degradation of the transcription factor Twist, an oncoprotein that promotes cancer metastasis.Regulation of Skp2 levels by the Pim-1 protein kinase Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex Akt: a double-edged sword in cell proliferation and genome stability.The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth.Androgen suppresses the proliferation of androgen receptor-positive castration-resistant prostate cancer cells via inhibition of Cdk2, CyclinA, and Skp2.Genetically engineered mouse models of PI3K signaling in breast cancer.A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth.Cullins and cancer.Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.Ezetimibe prevents the development of non‑alcoholic fatty liver disease induced by high‑fat diet in C57BL/6J mice.Cytoplasmic Skp2 expression is associated with p-Akt1 and predicts poor prognosis in human breast carcinomas The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway.SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction Regulation of Akt signaling activation by ubiquitination.Skp2 overexpression is associated with loss of BRCA2 protein in human prostate cancer.Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation

P2860

Q24292805-6FA4B95B-11DD-4E28-9916-54084148B3DD Q24595068-9EE53DA0-56C3-4FDB-A4C5-27876B2132CA Q24613186-08A6CCED-CD63-4DD7-8387-97029B0CE387 Q24625558-2ACC18C3-2B36-4FCE-AA82-F6B097E94322 Q26776456-590F2363-1B16-4D4F-B27C-0C4C7E4DEBAA Q26998944-8F3A4183-EFF7-4F2A-A7AD-99C88055B6F3 Q27027815-9B5E3444-616F-4A08-ADB6-AB1442AF0B48 Q28116106-9EECC3D5-884C-4092-B66F-00E76A0560B2 Q28251026-795043BD-6C0D-41AF-BC8E-A318908C4AC3 Q28273339-A09B0390-3C03-4C60-A334-70B7A598F452 Q28484382-C6E1ECD5-19FF-476F-9696-BA390EEFC051 Q30276974-AB11140E-9ADF-4492-A877-9EFB9C3828A8 Q30471196-C0F156E0-2CBB-4F31-9521-B37CDA8CCA48 Q30494570-D1AF792A-F9DA-44B2-B0AE-B0FDC800B637 Q33350237-FD7DCBC5-7F9A-41AF-87D4-7B35A6F8B6FD Q33350410-5A289454-3019-4F82-B044-E890B9F6FD8F Q33608923-BDAE4D09-2E9F-49BB-8862-9F931ED8DC3D Q33721192-C0196E53-C4F2-48CF-AD00-507F4B23E6C9 Q33785602-ED87DCA4-B5CB-4A13-9566-6464347450C1 Q33826685-A25C15D8-A4EF-49AA-A5FB-45C9E00EAC84 Q33842900-F443AA22-EE62-4EC0-839B-A20E2808E9EE Q33924237-4BC7FB69-0D52-4DF5-B963-EB327A2FD387 Q34121488-E65C911B-C52A-44BA-A846-BDC8183ADE58 Q34125987-6A73A135-FE00-4DFC-B9B8-51C2FE9A1806 Q34205972-89B5FF32-E05D-4027-B914-900D6D9947E3 Q34223641-93E953E0-B105-4526-AE36-115928E16CAA Q34227747-DDDBE68B-0E3F-4EF5-AC19-CBCD8F13B93D Q34278855-26405AF4-E670-49DB-8AF1-C3159641A931 Q34332175-B036EF28-4052-4AE8-88E6-2029E90B8F23 Q34361366-05FE6767-3D50-4ED6-BE69-764141C13B13 Q34365216-79840893-BE22-4C2C-AA49-141E5C0B3E60 Q34430770-FB9926FC-15E8-46E9-8C3B-CD9A0DB6F7B8 Q34487963-A0B07D54-D5FB-43E6-AFDA-150C0C2C00DC Q34541027-62A2EC92-E9A6-414C-B4BC-59F71DA86636 Q34746718-C7E184C7-7ACA-492F-A6E6-289A690CA22C Q34788849-2FBA1615-5BCD-4648-9ED8-B30B8313B5C3 Q34799443-883FE14B-B999-4458-A7C8-E8BCD216E2C1 Q34838226-E50F3F48-325E-435E-8F3D-F81F1C21935C Q34998481-54F0297B-6E74-4D2E-B132-67B67CB15225 Q35018011-BD7C63EC-BA96-4F04-8A36-198A33ED2171

P2860

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

http://www.wikidata.org/entity/Q24602385

description

2009 nî lūn-bûn

@nan

2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@ast

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@en

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@nl

type

label

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@ast

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@en

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@nl

prefLabel

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@ast

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@en

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@nl

P1433

Q24602385-01B66EC5-7331-46EA-96A9-42DFFD1935BF

P1476

Q24602385-743BE5B5-CB34-4324-BA18-46FF63D4903A

P2093

Q24602385-07AF4FC3-B8FF-4C69-8750-AA82690F2F0F

Q24602385-9C375CB8-66D7-4AEB-B887-320C46FF84F2

Q24602385-9CD07716-C8DC-4A10-B8CF-4DB00C1C0B12

Q24602385-A221D3E3-D232-4016-8D63-F8B72628ABBF

P2860

Q24602385-050E19BC-E9F5-44DC-AE24-EB1F30CBB88C

Q24602385-0BC01829-C30F-4BF1-8789-69BF263048FF

Q24602385-0C4BB7F8-7E3D-473B-AD9D-46D278AB91B2

Q24602385-16DA8E5F-A5E0-439A-9D46-2798BE809E81

Q24602385-1C9375F5-38D7-444F-941C-F6F2187BA133

Q24602385-1F2594A9-A810-4FB2-AF2D-50EFD75B1CEF

Q24602385-35BB7725-4DD8-4186-A159-CAC982FADFBA

Q24602385-3675A1C0-55F1-4027-AEA5-53070F092263

Q24602385-37D52EA5-C5DC-4656-8AEC-D9906549D69A

Q24602385-3C768117-ABE1-4B17-97AF-B2DC5517A1EC

P2888

Q24602385-3A70F760-2FD4-4D19-9606-C343C84A315F

P304

Q24602385-CA790319-60CE-4256-95C1-D4375C7AEABA

P31

Q24602385-EE5A3B7A-5306-4726-8B9D-1BCC01048192

P3181

Q24602385-362D872B-2D60-4BEB-93AD-4333E6B78293

P356

Q24602385-687D9C2D-AC94-4C15-9A60-F92DB59B5EC4

P407

Q24602385-6DB0F930-4017-4216-BCFD-5E91B84B5354

P433

Q24602385-05EE9B26-9AA7-4562-891E-30249FE5EDEA

P478

Q24602385-CE9CE6BC-D08E-4BE8-BFC7-11808AACE5EF

P50

Q24602385-65FD43D0-2994-48D3-B608-796C0AA64FC8

Q24602385-FDD8D254-0400-44D2-B201-1C6A3AEC438D

P577

Q24602385-9BD796A8-CEC5-4A12-9F42-873E9C78197E

P5875

Q24602385-FB31D02D-AD3A-489A-9825-C34D473482DE

P6179

Q24602385-382018A8-4B3C-4BF7-8F20-A8D91AF69B42

P698

Q24602385-5371CF29-8388-47F2-B277-24463A6DB021

P921

Q24602385-24DFC750-4B1A-4BCB-A3FD-958FF7A958C7

Q24602385-EFDAE2BE-7DCC-4675-A8BE-B0D82CDBC56B

P932

Q24602385-25A8CE4C-04A8-474E-A9E2-06D6A3A034E9

P3181

P356

P1433

Nature Cell Biology

P1476

Phosphorylation by Akt1 promot ...... Cdh1-mediated Skp2 destruction

@en

P2093

Alan Tseng

http://www.w3.org/2001/XMLSchema#string

Alex Toker

http://www.w3.org/2001/XMLSchema#string

Hiroyuki Inuzuka

http://www.w3.org/2001/XMLSchema#string

Wenyi Wei

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

A cell cycle regulatory network controlling NF-kappaB subunit activity and function

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

P2888

P304

397-408

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

5039793

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/NCB1847

http://www.w3.org/2001/XMLSchema#string

P407

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

11

http://www.w3.org/2001/XMLSchema#string

P50

P577

2009-03-08T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

24186093

http://www.w3.org/2001/XMLSchema#string

P6179

1049656389

http://www.w3.org/2001/XMLSchema#string

P698

19270695

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

2910589

http://www.w3.org/2001/XMLSchema#string