Camptothecins: a review of their chemotherapeutic potential
about
Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitorIdentification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigreesPharmacological screening using an FXN-EGFP cellular genomic reporter assay for the therapy of Friedreich ataxiaGene-Set Local Hierarchical Clustering (GSLHC)--A Gene Set-Based Approach for Characterizing Bioactive Compounds in Terms of Biological Functional GroupsBiocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications.Dissection of DNA damage responses using multiconditional genetic interaction mapsPreliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2.Phase II study of 9-aminocamptothecin in previously treated lymphomas: results of Cancer and Leukemia Group B 9551.Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.Anticancer activities of genistein-topotecan combination in prostate cancer cells.A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery.Association between UGT1A1*28 polymorphisms and clinical outcomes of irinotecan-based chemotherapies in colorectal cancer: a meta-analysis in Caucasians.PAMAM-camptothecin conjugate inhibits proliferation and induces nuclear fragmentation in colorectal carcinoma cells.Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activityRNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation.Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenograftsA critical evaluation of drug delivery from ligand modified nanoparticles: Confounding small molecule distribution and efficacy in the central nervous system.Assessing the regioselectivity of OleD-catalyzed glycosylation with a diverse set of acceptors.Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expressionModulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues.UGT1A1 gene polymorphism: impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer.Topoisomerase as target for antibacterial and anticancer drug discovery.Design, Synthesis and Cytotoxicity Evaluation of New 2-Aryl-5, 6-Dihydropyrrolo[2, 1-a]Isoquinoline Derivatives as Topoisomerase Inhibitors.Carboxyl-terminated PAMAM-SN38 conjugates: synthesis, characterization, and in vitro evaluation.Synthesis, characterization, and evaluation of mPEG-SN38 and mPEG-PLA-SN38 micelles for cancer therapy.Dual-acting histone deacetylase-topoisomerase I inhibitors.An overview of quinoline as a privileged scaffold in cancer drug discovery.Synthesis and biological evaluation of 7-alkenyl homocamptothecins as potent topoisomerase I inhibitors.Synthesis and biological evaluation of novel homocamptothecins conjugating with dihydropyrimidine derivatives as potent topoisomerase I inhibitors.Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes.Upregulation of NOXA by 10-Hydroxycamptothecin plays a key role in inducing fibroblasts apoptosis and reducing epidural fibrosis.Cytotoxicity, genotoxicity and mechanism of action (via gene expression analysis) of the indole alkaloid aspidospermine (antiparasitic) extracted from Aspidosperma polyneuron in HepG2 cellsPotential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly(amidoamine) dendrimers.Modulation of microRNAs by phytochemicals in cancer: underlying mechanisms and translational significance.Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani.Preparation of pixantrone/poly(γ-glutamic acid) nanoparticles through complex self-assembly for oral chemotherapy.Substitution-inert trinuclear platinum complexes efficiently condense/aggregate nucleic acids and inhibit enzymatic activity.Super Natural II--a database of natural products.Investigation of parameters influencing incorporation, retention and cellular cytotoxicity in liposomal formulations of poorly soluble camptothecin.Evaluation of the cytotoxic effect of camptothecin solid lipid nanoparticles on MCF7 cells.
P2860
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P2860
Camptothecins: a review of their chemotherapeutic potential
description
2002 nî lūn-bûn
@nan
2002 թուականին հրատարակուած գիտական յօդուած
@hyw
2002 թվականին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Camptothecins: a review of their chemotherapeutic potential
@ast
Camptothecins: a review of their chemotherapeutic potential
@en
Camptothecins: a review of their chemotherapeutic potential
@nl
type
label
Camptothecins: a review of their chemotherapeutic potential
@ast
Camptothecins: a review of their chemotherapeutic potential
@en
Camptothecins: a review of their chemotherapeutic potential
@nl
altLabel
Camptothecins
@ast
Camptothecins
@en
prefLabel
Camptothecins: a review of their chemotherapeutic potential
@ast
Camptothecins: a review of their chemotherapeutic potential
@en
Camptothecins: a review of their chemotherapeutic potential
@nl
P2093
P3181
P1433
P1476
Camptothecins
@en
Camptothecins: a review of their chemotherapeutic potential
@en
P2093
Hulya Ulukan
Peter W Swaan
Peter W. Swaan
P304
P3181
P356
10.2165/00003495-200262140-00004
P407
P577
2002-01-01T00:00:00Z
P6179
1036692386