Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters
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X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives †Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site.Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3.Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding.Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents.Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3In vitro processing of human tumor necrosis factor-alpha.Characterization of a recombinant proteinase 3, the autoantigen in Wegener's granulomatosis and its reactivity with anti-neutrophil cytoplasmic autoantibodies.Structural and functional characterization of elastases from horse neutrophils.Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases.Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts.Inhibition of proteinase 3 by [alpha]1-antitrypsin in vitro predicts very fast inhibition in vivo.Influence of Charge Distribution at the Active Site Surface on the Substrate Specificity of Human Neutrophil Protease 3 and ElastaseProteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases
P2860
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P2860
Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters
description
1992 nî lūn-bûn
@nan
1992 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@ast
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@en
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@nl
type
label
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@ast
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@en
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@nl
prefLabel
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@ast
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@en
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@nl
P2093
P1476
Human neutrophil proteinase 3: ...... ing peptidyl thiobenzyl esters
@en
P2093
J R Hoidal
M J Brubaker
W C Groutas
P304
P356
10.1016/0006-291X(92)91375-Z
P407
P577
1992-11-16T00:00:00Z