Influence of Charge Distribution at the Active Site Surface on the Substrate Specificity of Human Neutrophil Protease 3 and Elastase
about
New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases.Two lytic transglycosylases in Neisseria gonorrhoeae impart resistance to killing by lysozyme and human neutrophils.Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseasesMechanism of heparin acceleration of tissue inhibitor of metalloproteases-1 (TIMP-1) degradation by the human neutrophil elastaseNeutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamidesELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiologyInhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents.Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis.Human neutrophil elastase responsive delivery from poly(ethylene glycol) hydrogels.Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates.A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors.Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3.Protease inhibitors derived from elafin and SLPI and engineered to have enhanced specificity towards neutrophil serine proteases.Catalytic activity and inhibition of wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils.Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitisDifferences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase
P2860
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P2860
Influence of Charge Distribution at the Active Site Surface on the Substrate Specificity of Human Neutrophil Protease 3 and Elastase
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im November 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 2006
@uk
name
Influence of Charge Distributi ...... rophil Protease 3 and Elastase
@en
Influence of Charge Distributi ...... rophil Protease 3 and Elastase
@nl
type
label
Influence of Charge Distributi ...... rophil Protease 3 and Elastase
@en
Influence of Charge Distributi ...... rophil Protease 3 and Elastase
@nl
prefLabel
Influence of Charge Distributi ...... rophil Protease 3 and Elastase
@en
Influence of Charge Distributi ...... rophil Protease 3 and Elastase
@nl
P2093
P2860
P356
P1476
Influence of charge distributi ...... nd molecular modeling analysis
@en
P2093
Eric Hajjar
Francis Gauthier
Luiz Juliano
Michèle Brillard-Bourdet
Thierry Moreau
Timofey Kalupov
P2860
P304
P356
10.1074/JBC.M608700200
P407
P577
2006-11-06T00:00:00Z