Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen - Wikidata - wikimedia - TriplyDB

Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen

Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen

http://www.wikidata.org/entity/Q28205871

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Crystallographic insight into collagen recognition by discoidin domain receptor 2 Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation Structural basis of the collagen-binding mode of discoidin domain receptor 2 Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling Molecular biology of lung cancer Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen Discoidin Domain Receptors: Potential Actors and Targets in Cancer Targeted therapies for patients with advanced NSCLC harboring wild-type EGFR: what's new and what's enough Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2 Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver Discoidin domain receptors in disease.Discoidin domain receptor functions in physiological and pathological conditions.Discoidin domain receptor 1: isoform expression and potential functions in cirrhotic human liver.Collagen recognition and transmembrane signalling by discoidin domain receptors From scarless fetal wounds to keloids: molecular studies in wound healing.Discoidin domain receptor tyrosine kinases: new players in cancer progression Genetic changes in squamous cell lung cancer: a review Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer.A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix.The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis Acquired resistance to dasatinib in lung cancer cell lines conferred by DDR2 gatekeeper mutation and NF1 loss.Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth.DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study.Role of genotyping in non-small cell lung cancer treatment: current status.Genetic insight and therapeutic targets in squamous-cell lung cancer.The role of cell-extracellular matrix interactions in glomerular injury.Rare mutations in non-small-cell lung cancer.Receptor tyrosine kinase alterations and therapeutic opportunities in squamous cell carcinoma of the lung.Discoidin domain receptors: a proteomic portrait.Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib.Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy.Quantitative chemical proteomics identifies novel targets of the anti-cancer multi-kinase inhibitor E-3810.Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family member.Loss of discoidin domain receptor 2 promotes hepatic fibrosis after chronic carbon tetrachloride through altered paracrine interactions between hepatic stellate cells and liver-associated macrophages.Exploring the collagen-binding site of the DDR1 tyrosine kinase receptor.Impaired dermal wound healing in discoidin domain receptor 2-deficient mice associated with defective extracellular matrix remodeling.Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts.

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P2860

Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen

http://www.wikidata.org/entity/Q28205871

description

2002 nî lūn-bûn

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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2002 թվականի մայիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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name

Discoidin domain receptor 2 in ...... activation by type I collagen

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Discoidin domain receptor 2 in ...... activation by type I collagen

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Discoidin domain receptor 2 in ...... activation by type I collagen

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type

label

Discoidin domain receptor 2 in ...... activation by type I collagen

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Discoidin domain receptor 2 in ...... activation by type I collagen

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Discoidin domain receptor 2 in ...... activation by type I collagen

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prefLabel

Discoidin domain receptor 2 in ...... activation by type I collagen

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Discoidin domain receptor 2 in ...... activation by type I collagen

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Discoidin domain receptor 2 in ...... activation by type I collagen

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P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Discoidin domain receptor 2 in ...... activation by type I collagen

@en

P2093

David Lovett

http://www.w3.org/2001/XMLSchema#string

Elvira Olaso

http://www.w3.org/2001/XMLSchema#string

Francis J Eng

http://www.w3.org/2001/XMLSchema#string

George D Yancopoulos

http://www.w3.org/2001/XMLSchema#string

Hong Zhao

http://www.w3.org/2001/XMLSchema#string

Hsin Chieh Lin

http://www.w3.org/2001/XMLSchema#string

Kazuo Ikeda

http://www.w3.org/2001/XMLSchema#string

Li-Hsien Wang

http://www.w3.org/2001/XMLSchema#string

Richard Torres

http://www.w3.org/2001/XMLSchema#string

Scott L Friedman

http://www.w3.org/2001/XMLSchema#string

P2860

The discoidin domain receptor tyrosine kinases are activated by collagen

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

Protein modules and signalling networks

Integrins: versatility, modulation, and signaling in cell adhesion

Discoidin domain receptor 1 is activated independently of beta(1) integrin

An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors

The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism.

Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells

P304

19206-19212

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scholarly article

P356

10.1074/JBC.M201078200

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P407

P433

21

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P478

277

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P50

Juan Pablo Labrador

P577

2002-03-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

11884411

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