GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration
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G protein-coupled receptor kinase 2 positively regulates epithelial cell migrationASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasionGIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnoverPaxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamicsSynapse formation is regulated by the signaling adaptor GIT1.A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegansPhosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnoverRegulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.Biochemical and functional characterization of the interaction between liprin-α1 and GIT1: implications for the regulation of cell motilitySrc and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.Identification of phosphorylation sites in betaPIX and PAK1N-ethylmaleimide-sensitive factor attachment protein α (αSNAP) regulates matrix adhesion and integrin processing in human epithelial cellsIdentification of two tyrosine residues required for the intramolecular mechanism implicated in GIT1 activation.G-protein-coupled receptor kinase interactor-1 (GIT1) is a new endothelial nitric-oxide synthase (eNOS) interactor with functional effects on vascular homeostasis.Regulation of actin cytoskeleton dynamics by Arf-family GTPases.Integrins in cell migration--the actin connection.alpha5 integrin signaling regulates the formation of spines and synapses in hippocampal neurons.FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDIIdentification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration.A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells.Endothelial nitric-oxide synthase (eNOS) is activated through G-protein-coupled receptor kinase-interacting protein 1 (GIT1) tyrosine phosphorylation and Src proteinMicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasisEmerging role of paxillin-PKL in regulation of cell adhesion, polarity and migrationConstitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesionsControl of synapse development and plasticity by Rho GTPase regulatory proteins.Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contactsNuclear GIT2 is an ATM substrate and promotes DNA repairEffects of HER2 overexpression on cell signaling networks governing proliferation and migration.The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreadingSorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (β-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction.Inhibiting the Recruitment of PLCγ1 to Kaposi's Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial CellsPAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationGIT1 utilizes a focal adhesion targeting-homology domain to bind paxillinTyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.Receptor type protein tyrosine phosphatases (RPTPs) - roles in signal transduction and human disease.The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.
P2860
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P2860
GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
GIT1 functions in a motile, mu ...... ve activity and cell migration
@ast
GIT1 functions in a motile, mu ...... ve activity and cell migration
@en
GIT1 functions in a motile, mu ...... ve activity and cell migration
@nl
type
label
GIT1 functions in a motile, mu ...... ve activity and cell migration
@ast
GIT1 functions in a motile, mu ...... ve activity and cell migration
@en
GIT1 functions in a motile, mu ...... ve activity and cell migration
@nl
prefLabel
GIT1 functions in a motile, mu ...... ve activity and cell migration
@ast
GIT1 functions in a motile, mu ...... ve activity and cell migration
@en
GIT1 functions in a motile, mu ...... ve activity and cell migration
@nl
P2093
P3181
P1476
GIT1 functions in a motile, mu ...... ve activity and cell migration
@en
P2093
Donna J Webb
Mykola Kovalenko
Ri-ichiroh Manabe
P304
P3181
P407
P577
2002-04-01T00:00:00Z