Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection
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Sheep lung segmental delivery strategy demonstrates adenovirus priming of local lung responses to bacterial LPS and the role of elafin as a response modulatorTranscriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defenseWFDC1 is a key modulator of inflammatory and wound repair responsesDynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytesStructural and antimicrobial properties of human pre-elafin/trappin-2 and derived peptides against Pseudomonas aeruginosa.Anti-inflammatory and antimicrobial roles of secretory leukocyte protease inhibitor.Antimicrobial activity of murine lung cells against Staphylococcus aureus is increased in vitro and in vivo after elafin gene transfer.Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:CAnti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells.Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafinThe serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase.Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice.Clinical review: gene-based therapies for ALI/ARDS: where are we now?Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute RejectionAnti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cellsPsoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins.Neutrophil serine proteases: potential key regulators of cell signalling during inflammation.Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidantsNeonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growthEndogenous pulmonary antibiotics.A genome-wide expression analysis in blood identifies pre-elafin as a biomarker in ARDS.Human rElafin Inhibits HIV-1 Replication in Its Natural Target Cells.Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitmentIdentification of cancer initiating cells in K-Ras driven lung adenocarcinoma.Secretory leukocyte protease inhibitor and elafin/trappin-2: versatile mucosal antimicrobials and regulators of immunity.Biological roles of host defense peptides: lessons from transgenic animals and bioengineered tissues.Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection.WAP domain proteins as modulators of mucosal immunity.Inflammatory gene signature in ulcerative colitis with cDNA macroarray analysis.Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury.c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinomaRecombinant human elafin protects airway epithelium integrity during inflammation.Elafin (SKALP/Trappin-2/proteinase inhibitor-3) is produced by the cervix in pregnancy and cervicovaginal levels are diminished in bacterial vaginosis.Antiproteases as therapeutics to target inflammation in cystic fibrosis.Protease inhibitors derived from elafin and SLPI and engineered to have enhanced specificity towards neutrophil serine proteases.IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides.Characterization of human pre-elafin mutants: full antipeptidase activity is essential to preserve lung tissue integrity in experimental emphysema.Rhesus Theta (θ)-Defensin-1 Attenuates Endotoxin-Induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment.The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function.
P2860
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P2860
Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Adenoviral augmentation of ela ...... ophils and bacterial infection
@ast
Adenoviral augmentation of ela ...... ophils and bacterial infection
@en
Adenoviral augmentation of ela ...... ophils and bacterial infection
@nl
type
label
Adenoviral augmentation of ela ...... ophils and bacterial infection
@ast
Adenoviral augmentation of ela ...... ophils and bacterial infection
@en
Adenoviral augmentation of ela ...... ophils and bacterial infection
@nl
prefLabel
Adenoviral augmentation of ela ...... ophils and bacterial infection
@ast
Adenoviral augmentation of ela ...... ophils and bacterial infection
@en
Adenoviral augmentation of ela ...... ophils and bacterial infection
@nl
P2093
P1476
Adenoviral augmentation of ela ...... ophils and bacterial infection
@en
P2093
D J Porteous
J M Sallenave
M E Marsden
W A Wallace
P304
P356
10.4049/JIMMUNOL.167.3.1778
P407
P50
P577
2001-08-01T00:00:00Z