Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes
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Niemann-Pick disease type CProteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migrationCholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cellsDeficiency of niemann-pick type C-1 protein impairs release of human immunodeficiency virus type 1 and results in Gag accumulation in late endosomal/lysosomal compartmentsRab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cellsMolecular pathways for intracellular cholesterol accumulation: common pathogenic mechanisms in Niemann-Pick disease Type C and cystic fibrosisMutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution.Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.Components of the antigen processing and presentation pathway revealed by gene expression microarray analysis following B cell antigen receptor (BCR) stimulationARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C diseaseNiemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo.Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane.Niemann-Pick type C disease and intracellular cholesterol trafficking.Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex.PKC activation in Niemann pick C1 cells restores subcellular cholesterol transportAn "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease.Cholesterol controls lipid endocytosis through Rab11.ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis.Lipid imbalance in the neurological disorder, Niemann-Pick C disease.Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complexDevelopment of a Rab9 transgenic mouse and its ability to increase the lifespan of a murine model of Niemann-Pick type C disease.[Enhanced control of proliferation in telomerized cells].New therapies in the management of Niemann-Pick type C disease: clinical utility of miglustatBinding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain.Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recyclingTreatable metabolic psychoses that go undetected: what Niemann-Pick type C can teach us.Endosomal cholesterol trafficking: protein factors at a glance.LDL-cholesterol transport to the endoplasmic reticulum: current concepts.Routes and mechanisms of post-endosomal cholesterol trafficking: A story that never ends.Increased copper levels in in vitro and in vivo models of Niemann-Pick C disease.Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment.Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.Distribution and trafficking of MPR300 is normal in cells with cholesterol accumulated in late endocytic compartments: evidence for early endosome-to-TGN trafficking of MPR300.NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein.Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.Roles of endogenously synthesized sterols in the endocytic pathway.Copper incorporation into ceruloplasmin is regulated by Niemann-Pick C1 protein.
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P2860
Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@ast
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@en
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@nl
type
label
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@ast
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@en
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@nl
prefLabel
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@ast
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@en
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@nl
P2093
P2860
P3181
P1476
Telomerase immortalization upr ...... Niemann-Pick C1 late endosomes
@en
P2093
Joanna P Davies
Marc Walter
Yiannis A Ioannou
P2860
P304
P3181
P356
10.1194/JLR.M200230-JLR200
P407
P577
2003-02-01T00:00:00Z