Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.
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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammationCholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasisNiemann-Pick Type C disease: characterizing lipid levels in patients with variant lysosomal cholesterol storage.Phenotypic screens as a renewed approach for drug discovery.δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders.Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes.Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C diseaseAnalysis of cholesterol trafficking with fluorescent probes.Physiological difference in autophagic flux in macrophages from 2 mouse strains regulates cholesterol ester metabolismNiemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches.Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation.Quantitative Co-Localization and Pattern Analysis of Endo-Lysosomal Cargo in Subcellular Image Cytometry and Validation on Synthetic Image Sets.Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells.Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages.Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics.Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease.Modeling Niemann-Pick disease type C1 in zebrafish: a robust platform for screening of candidate therapeutic compounds
P2860
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P2860
Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Chemical screen to reduce ster ...... osomal acid lipase inhibitors.
@ast
Chemical screen to reduce ster ...... osomal acid lipase inhibitors.
@en
type
label
Chemical screen to reduce ster ...... osomal acid lipase inhibitors.
@ast
Chemical screen to reduce ster ...... osomal acid lipase inhibitors.
@en
prefLabel
Chemical screen to reduce ster ...... osomal acid lipase inhibitors.
@ast
Chemical screen to reduce ster ...... osomal acid lipase inhibitors.
@en
P2093
P2860
P1476
Chemical screen to reduce ster ...... osomal acid lipase inhibitors.
@en
P2093
Amy Y Huang
Anton I Rosenbaum
Frederick R Maxfield
Gregory A Grabowski
Madalina Rujoi
P2860
P304
P356
10.1016/J.BBALIP.2009.08.005
P407
P577
2009-08-20T00:00:00Z