The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis - Wikidata - wikimedia - TriplyDB

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

http://www.wikidata.org/entity/Q28208308

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Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C.Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration.Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3.Processing of proaugurin is required to suppress proliferation of tumor cell lines.Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells Ovarian furin (proprotein convertase subtilisin/kexin type3): expression, localization, and potential role in ovulation in the rat.Lymphangiogenesis and lymphatic metastasis in breast cancer.Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis Vascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancer ProSAAS-derived peptides are differentially processed and sorted in mouse brain and AtT-20 cells Repression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases.Identification of proprotein convertase substrates using genome-wide expression correlation analysis.Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity.When it comes to blocking lymphatics, it is all a question of time Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3 Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1alpha) and the HIF-1alpha target gene DEC1, but not lymph node metastasis in primary human breast carcinomas Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.The role of angiogenic factors in endometrial cancer.Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.Loss of endothelial furin leads to cardiac malformation and early postnatal death.Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway.Targeting lymphangiogenesis to prevent tumour metastasis A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness.Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells.The proprotein convertase furin is required for trophoblast syncytialization E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-β in the bone microenvironment Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Elevated in Patients With Peripheral Artery Disease and Associated With Metabolic Disorders and Dysfunction in Circulating Progenitor Cells.Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.The non-canonical role of vascular endothelial growth factor-C axis in cancer progression Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor β1a (TGFβ1a).Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D.T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.

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The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis

http://www.wikidata.org/entity/Q28208308

description

2003 nî lūn-bûn

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2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

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The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

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The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

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type

label

The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

@ast

The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

@en

The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

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prefLabel

The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

@ast

The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

@en

The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

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Journal of Clinical Investigation

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The secretory proprotein conve ...... VEGF-C to induce tumorigenesis

@en

P2093

Abdel-Majid Khatib

http://www.w3.org/2001/XMLSchema#string

Ajoy Basak

http://www.w3.org/2001/XMLSchema#string

Geraldine Siegfried

http://www.w3.org/2001/XMLSchema#string

Jadwiga Marcinkiewicz

http://www.w3.org/2001/XMLSchema#string

James A Cromlish

http://www.w3.org/2001/XMLSchema#string

Michel Chrétien

http://www.w3.org/2001/XMLSchema#string

Nabil G Seidah

http://www.w3.org/2001/XMLSchema#string

Suzanne Benjannet

http://www.w3.org/2001/XMLSchema#string

P2860

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

Proteolytic processing regulates receptor specificity and activity of VEGF-C.

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4

Regulation of cell survival by secreted proneurotrophins.

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

Hyperplasia of lymphatic vessels in VEGF-C transgenic mice

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1723-32

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scholarly article

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1468844

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10.1172/JCI17220

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11

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111

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2003-06-01T00:00:00Z

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10728471

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12782675

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156106

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