Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism
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ACTH Regulation of Adrenal SR-B1What does procollagen C-endopeptidase enhancer protein 2 have to do with HDL-cholesteryl ester uptake? Or how I learned to stop worrying and love reverse cholesterol transport?Hepatoma Cell Density Promotes Claudin-1 and Scavenger Receptor BI Expression and Hepatitis C Virus InternalizationIn Vitro and in Vivo Analysis of the Binding of the C Terminus of the HDL Receptor Scavenger Receptor Class B, Type I (SR-BI), to the PDZ1 Domain of Its Adaptor Protein PDZK1Identification of the PDZ3 Domain of the Adaptor Protein PDZK1 as a Second, Physiologically Functional Binding Site for the C Terminus of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type ISR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate CancerSilver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE ReceptorRare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart diseaseExtrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice.Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins.Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice.Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice.Sensing of dietary lipids by enterocytes: a new role for SR-BI/CLA-1Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease.Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.The SR-BI partner PDZK1 facilitates hepatitis C virus entry.Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling.Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BIA regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization.Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1.microRNAs and HDL life cycle.MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells.Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface.A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI.Normal hepatic cell surface localization of the high density lipoprotein receptor, scavenger receptor class B, type I, depends on all four PDZ domains of PDZK1.PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1.Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissuesRas/mitogen-activated protein kinase (MAPK) signaling modulates protein stability and cell surface expression of scavenger receptor SR-BI.Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis.Lipid abnormalities in alpha/beta2-syntrophin null mice are independent from ABCA1.PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle.Protein mediators of sterol transport across intestinal brush border membrane.Thematic review series: the immune system and atherogenesis. Recent insights into the biology of macrophage scavenger receptors.PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes.HDL action on the vascular wall: is the answer NO?NHERF family and NHE3 regulation.The emerging role of PDZ adapter proteins for regulation of intestinal ion transport.
P2860
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P2860
Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@ast
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@en
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@nl
type
label
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@ast
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@en
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@nl
prefLabel
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@ast
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@en
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@nl
P2093
P2860
P921
P3181
P356
P1476
Targeted disruption of the PDZ ...... altered lipoprotein metabolism
@en
P2093
Attilio Rigotti
Ayce Yesilaltay
Christine Cirovic
Monty Krieger
Olivier Kocher
P2860
P304
P3181
P356
10.1074/JBC.M310482200
P407
P577
2003-12-26T00:00:00Z