Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization
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The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human CancerOn systems and control approaches to therapeutic gain.DNA damage signaling, impairment of cell cycle progression, and apoptosis triggered by 5-ethynyl-2'-deoxyuridine incorporated into DNA.YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.Integration of Principles of Systems Biology and Radiation Biology: Toward Development of in silico Models to Optimize IUdR-Mediated Radiosensitization of DNA Mismatch Repair Deficient (Damage Tolerant) Human Cancers.Detection and imaging of the free radical DNA in cells--site-specific radical formation induced by Fenton chemistry and its repair in cellular DNA as seen by electron spin resonance, immuno-spin trapping and confocal microscopy.5-iodo-2-pyrimidinone-2'-deoxyribose-mediated cytotoxicity and radiosensitization in U87 human glioblastoma xenografts.The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine.Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer.Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation.Methoxyamine Enhances 5-Fluorouracil-Induced Radiosensitization in Colon Cancer Cell Line HT29.Effects of resveratrol and methoxyamine on the radiosensitivity of iododeoxyuridine in U87MG glioblastoma cell line.The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions.Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair.Developing an in silico model of the modulation of base excision repair using methoxyamine for more targeted cancer therapeutics.Phase I clinical trial of the base excision repair inhibitor methoxyamine in combination with fludarabine for patients with advanced hematologic malignancies.
P2860
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P2860
Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Inhibition of base excision re ...... oxicity and radiosensitization
@ast
Inhibition of base excision re ...... oxicity and radiosensitization
@en
Inhibition of base excision re ...... oxicity and radiosensitization
@nl
type
label
Inhibition of base excision re ...... oxicity and radiosensitization
@ast
Inhibition of base excision re ...... oxicity and radiosensitization
@en
Inhibition of base excision re ...... oxicity and radiosensitization
@nl
prefLabel
Inhibition of base excision re ...... oxicity and radiosensitization
@ast
Inhibition of base excision re ...... oxicity and radiosensitization
@en
Inhibition of base excision re ...... oxicity and radiosensitization
@nl
P2093
P1433
P1476
Inhibition of base excision re ...... oxicity and radiosensitization
@en
P2093
David A Zarling
Guru Reddy
Hwa-Shin Hwang
Jane E Schupp
Nancy Nguyen Session
Pietro Taverna
Timothy J Kinsella
Tomas Radivoyevitch
P304
P407
P577
2003-02-15T00:00:00Z