Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast
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Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase IICrystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide LigandIn vitro and in vivo antifungal activities of DU-6859a, a fluoroquinolone, in combination with amphotericin B and fluconazole against pathogenic fungiCharacterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacinA mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase IIPiperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells.Use of a recombination reporter insert to define meiotic recombination domains on chromosome III of Saccharomyces cerevisiaeDNA topoisomerase II sites in the histone H4 gene during the highly synchronous cell cycle of Physarum polycephalumYeast recombination pathways triggered by topoisomerase II-mediated DNA breaks.Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.Novel 1-8-bridged chiral quinolones with activity against topoisomerase II: stereospecificity of the eukaryotic enzyme.Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potentialTrimethoxy-benzaldehyde levofloxacin hydrazone inducing the growth arrest and apoptosis of human hepatocarcinoma cells.A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.CP-115,953 stimulates cytokine production by lymphocytes.Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase.Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities.Stereo (C7)-dependent topoisomerase II inhibition and tumor growth suppression by a new quinolone, BO-2367.
P2860
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P2860
Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast
description
1992 nî lūn-bûn
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1992 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1992年の論文
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1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
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name
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@ast
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@en
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@nl
type
label
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@ast
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@en
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@nl
prefLabel
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@ast
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@en
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@nl
P2093
P1476
Cytotoxicity of quinolones tow ...... quinolone CP-115,953 in yeast
@en
P2093
P304
P407
P577
1992-07-05T00:00:00Z