Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.
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Bioflavonoids as poisons of human topoisomerase II alpha and II betaPiperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells.Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavageActivity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.Novel N-2-(Furyl)-2-(chlorobenzyloxyimino) Ethyl Piperazinyl Quinolones: Synthesis, Cytotoxic Evaluation and Structure-Activity Relationship.The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.DNA topoisomerase II, genotoxicity, and cancerTrimethoxy-benzaldehyde levofloxacin hydrazone inducing the growth arrest and apoptosis of human hepatocarcinoma cells.A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.Embryotoxic and teratogenic effects of norfloxacin in pregnant female albino ratsLong-term effects of chromatin remodeling and DNA damage in stem cells induced by environmental and dietary agents.A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors.Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions.Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase.CP-115,953 stimulates cytokine production by lymphocytes.Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner.A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods.Heterocycles [h]fused onto 4-oxoquinoline-3-carboxylic acid, part IV. Convenient synthesis of substituted hexahydro [1,4]thiazepino[2,3-h]quinoline-9-carboxylic acid and its tetrahydroquino[7,8-b]benzothiazepine homolog.Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities.Topoisomerase IV catalysis and the mechanism of quinolone action.A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
P2860
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P2860
Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Drug features that contribute ...... vitro and cytotoxic potential.
@ast
Drug features that contribute ...... vitro and cytotoxic potential.
@en
type
label
Drug features that contribute ...... vitro and cytotoxic potential.
@ast
Drug features that contribute ...... vitro and cytotoxic potential.
@en
prefLabel
Drug features that contribute ...... vitro and cytotoxic potential.
@ast
Drug features that contribute ...... vitro and cytotoxic potential.
@en
P2093
P2860
P356
P1476
Drug features that contribute ...... vitro and cytotoxic potential.
@en
P2093
M Moynihan
N Osheroff
P R McGuirk
P2860
P304
P356
10.1128/AAC.37.10.2179
P407
P577
1993-10-01T00:00:00Z