Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
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HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cellsDifferential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemiaExpression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic miceVirally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cellsHigh levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming eventA new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemiasEmbryonic fibroblasts from mice lacking Tgif were defective in cell cyclingRapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies.The vent-like homeobox gene VENTX promotes human myeloid differentiation and is highly expressed in acute myeloid leukemia.Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion.The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets.HoxA10 regulates transcription of the gene encoding transforming growth factor beta2 (TGFbeta2) in myeloid cells.Human hematopoietic lineage commitment.HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1.Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivoZearalenone mycotoxin affects immune mediators, MAPK signalling molecules, nuclear receptors and genome-wide gene expression in pig spleen.The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signalingHoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells.Hox genes: from leukemia to hematopoietic stem cell expansion.Transcriptional repression of CDKN2D by PML/RARα contributes to the altered proliferation and differentiation block of acute promyelocytic leukemia cells.β-Catenin activates the HOXA10 and CDX4 genes in myeloid progenitor cells.The leukemia-associated Mll-Ell oncoprotein induces fibroblast growth factor 2 (Fgf2)-dependent cytokine hypersensitivity in myeloid progenitor cells.Aldehyde dehydrogenase-1a1 induces oncogene suppressor genes in B cell populations.Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells.Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesisThe role of HOX genes in normal hematopoiesis and acute leukemia.Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex.Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4.Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells.Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP).Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction.Regulatory interdependence of myeloid transcription factors revealed by Matrix RNAi analysis.FANTOM4 EdgeExpressDB: an integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions.Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells.The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model.Transcriptional Regulation of Emergency Granulopoiesis in Leukemia.
P2860
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P2860
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
description
2001 nî lūn-bûn
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2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@ast
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@en
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@nl
type
label
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@ast
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@en
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@nl
prefLabel
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@ast
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@en
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@nl
P2093
P356
P1433
P1476
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
@en
P2093
J Antonchuk
M Feuring-Buske
R K Humphries
P304
P356
10.1182/BLOOD.V97.8.2286
P407
P577
2001-04-15T00:00:00Z