Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
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Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblastsStra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosisIdentification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathwayNur77 upregulates HIF-alpha by inhibiting pVHL-mediated degradationGene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancersThe Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and DiseaseHIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionTherapeutic considerations for Mdm2: not just a one trick ponyA Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional ActivityHypoxia-inducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells.TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death.MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner.p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia.Inhibition of endothelial cell proliferation and tumor angiogenesis by up-regulating NDRG2 expression in breast cancer cells.Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies.Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells.Targeted genes and interacting proteins of hypoxia inducible factor-1.Reciprocal influence of the p53 and the hypoxic pathwaysUp-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cellsHIF-1α and HIF-2α: siblings in promoting angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation.Computational analysis of signaling patterns in single cells.Improved diabetic wound healing through topical silencing of p53 is associated with augmented vasculogenic mediatorsHypoxia, stem cells and bone tumorActivation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.Hypoxia-inducible factor-1 and oncogenic signalling.Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis.Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosisProperties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system.HIF-1 and p53: communication of transcription factors under hypoxia.Modeling the interplay between the HIF-1 and p53 pathways in hypoxiaHypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!Metabolic stress in autophagy and cell death pathwaysTranscriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology?Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cellsPharmacologic activation of p53 by small-molecule MDM2 antagonistsDNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.
P2860
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P2860
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@ast
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@en
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@nl
type
label
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@ast
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@en
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@nl
prefLabel
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@ast
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@en
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@nl
P2093
P2860
P356
P1476
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
@en
P2093
P2860
P304
P356
10.1074/JBC.C200694200
P407
P577
2003-04-18T00:00:00Z