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Estimating cell depth from somatic mutationsGenomic variability within an organism exposes its cell lineage treeDiffering patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6Mouse models of intestinal cancerComparing algorithms that reconstruct cell lineage trees utilizing information on microsatellite mutationsMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesFunctional residues on the surface of the N-terminal domain of yeast Pms1Mechanisms and functions of DNA mismatch repairCharacterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2DNA replication fidelity and cancerExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationMouse models of human familial cancer syndromes.Mismatch repair and treatment resistance in ovarian cancer.Reconstruction of cell lineage trees in miceEffect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cellsSelective induction of DNA repair pathways in human B cells activated by CD4+ T cellsMutator suppression and escape from replication error-induced extinction in yeastThe nucleotide binding dynamics of human MSH2-MSH3 are lesion dependentMsh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in miceMouse models of inherited cancer syndromesA role for DNA mismatch repair protein Msh2 in error-prone double-strand-break repair in mammalian chromosomesAID and mismatch repair in antibody diversification.Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approachesFusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoproteinIncreased incidence of endometrioid tumors caused by aberrations in E-cadherin promoter of mismatch repair-deficient mice.Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops.Genetics of skin appendage neoplasms and related syndromes.Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelityMlh1 deficiency in zebrafish results in male sterility and aneuploid as well as triploid progeny in females.Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.Accurate homologous recombination is a prominent double-strand break repair pathway in mammalian chromosomes and is modulated by mismatch repair protein Msh2.A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequencyGenetically engineered mouse models in cancer researchEmergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast.Endonuclease activities of MutLα and its homologs in DNA mismatch repair.Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications.Familial T-cell non-Hodgkin lymphoma caused by biallelic MSH2 mutationsCompletion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1.DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas.
P2860
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P2860
description
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Juli 2002 veröffentlicher wissenschaftlicher Artikel
@de
scientific article (publication date: July 2002)
@en
vedecký článok (publikovaný 2002-07)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd in 2002-07)
@nl
наукова стаття, опублікована в липні 2002
@uk
مقالة علمية (نشرت في يوليو 2002)
@ar
name
Mouse models for human DNA mismatch-repair gene defects
@ast
Mouse models for human DNA mismatch-repair gene defects
@en
Mouse models for human DNA mismatch-repair gene defects
@nl
type
label
Mouse models for human DNA mismatch-repair gene defects
@ast
Mouse models for human DNA mismatch-repair gene defects
@en
Mouse models for human DNA mismatch-repair gene defects
@nl
prefLabel
Mouse models for human DNA mismatch-repair gene defects
@ast
Mouse models for human DNA mismatch-repair gene defects
@en
Mouse models for human DNA mismatch-repair gene defects
@nl
P2093
P3181
P1476
Mouse models for human DNA mismatch-repair gene defects
@en
P2093
Kaichun Wei
Raju Kucherlapati
Winfried Edelmann
P304
P3181
P356
10.1016/S1471-4914(02)02359-6
P407
P577
2002-07-01T00:00:00Z