BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions
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BRCA1 affects global DNA methylation through regulation of DNMT1Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1bControl of biochemical reactions through supramolecular RING domain self-assembly.STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complexThe role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapyRegulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligaseNuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1Identification of residues required for the interaction of BARD1 with BRCA1Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 proteinIs there more to BARD1 than BRCA1?Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forksBARD1 participates with BRCA1 in homology-directed repair of chromosome breaksSubstitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature.Assessment of human Nter and Cter BRCA1 mutations using growth and localization assays in yeast.Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.The BARD1 Cys557Ser variant and breast cancer risk in IcelandThe ubiquitin system, disease, and drug discovery.BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility.Self-assembly properties of a model RING domainBRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies.BRIZ1 and BRIZ2 proteins form a heteromeric E3 ligase complex required for seed germination and post-germination growth in Arabidopsis thalianaUnderstanding missense mutations in the BRCA1 gene: an evolutionary approach.Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.The role of BRCA1 in DNA damage response.Characterization of BRCA1 ring finger variants of uncertain significanceCharacterization of an Italian founder mutation in the RING-finger domain of BRCA1.Classification of BRCA1 missense variants of unknown clinical significance.Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer.Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies.Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network.Cancer. BRCA1, everything but the RING?Breast cancer gene variants: separating the harmful from the harmless.The ubiquitin landscape at DNA double-strand breaks.Connecting the Dots: Interplay between Ubiquitylation and SUMOylation at DNA Double-Strand BreaksA Novel Model to Characterize Structure and Function of BRCA1.DNA damage induces p53-dependent BRCA1 nuclear export.Expression of cancer related BRCA1 missense variants decreases MMS-induced recombination in Saccharomyces cerevisiae without altering its nuclear localization.
P2860
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P2860
BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@ast
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@en
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@nl
type
label
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@ast
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@en
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@nl
prefLabel
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@ast
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@en
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@nl
P2093
P2860
P356
P1476
BRCA1 RING domain cancer-predi ...... n protein-protein interactions
@en
P2093
P2860
P304
P356
10.1074/JBC.M106551200
P407
P577
2001-11-02T00:00:00Z