The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
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Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligaseBARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinaseBRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic functionBRCA1 participates in DNA decatenationAbraxas and RAP80 form a BRCA1 protein complex required for the DNA damage responseHighlight: BRCA1 and BRCA2 proteins in breast cancerThe BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitinMERIT40 facilitates BRCA1 localization and DNA damage repairNBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint controlControl of biochemical reactions through supramolecular RING domain self-assembly.Negative Regulation of AKT Activation by BRCA1BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionStructural Basis of Targeting the Exportin CRM1 in CancerA guide for functional analysis of BRCA1 variants of uncertain significanceThe BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular LocationsBARD1 may be renamed ROW1 because it functions mainly as a REPRESSOR OF WUSCHEL1Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitinationMass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligaseNuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiationBARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear exportIs there more to BARD1 than BRCA1?Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageMinding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forksThe role of epigenetics in resistance to Cisplatin chemotherapy in lung cancerBRCA1 and Oxidative StressLoss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instabilityBARD1 participates with BRCA1 in homology-directed repair of chromosome breaksBuilding ubiquitin chains: E2 enzymes at workModulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression.A homologue of the breast cancer-associated gene BARD1 is involved in DNA repair in plantsThe BARD1 Cys557Ser variant and breast cancer risk in IcelandMutation of Arabidopsis BARD1 causes meristem defects by failing to confine WUSCHEL expression to the organizing center.Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants.Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha by displacing BARD1/BRCA1.Targeting tumor suppressor networks for cancer therapeutics.A strategy to apply quantitative epistasis analysis on developmental traits
P2860
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P2860
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@ast
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@en
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@nl
type
label
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@ast
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@en
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@nl
prefLabel
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@ast
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@en
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@nl
P3181
P1476
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
@en
P2093
Richard Baer
Thomas Ludwig
P3181
P356
10.1016/S0959-437X(01)00269-6
P407
P577
2002-02-01T00:00:00Z