The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
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Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolismMechanism of thioamide drug action against tuberculosis and leprosyStrategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosisEthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targetsThe prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenaseMycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosisIdentification of new drug targets and resistance mechanisms in Mycobacterium tuberculosisAn ethA-ethR-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo, which correlate with altered mycolic acid compositionCompounds for use in the treatment of mycobacterial infections: a patent evaluation (WO2014049107A1).EthA/R-Independent Killing of Mycobacterium tuberculosis by Ethionamide.Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.Cyclic di-GMP regulates Mycobacterium tuberculosis resistance to ethionamideFlavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones.Dataset of potential targets for Mycobacterium tuberculosis H37Rv through comparative genome analysisMolecular investigation of resistance to the antituberculous drug ethionamide in multidrug-resistant clinical isolates of Mycobacterium tuberculosisBioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases.Current status and future development of antitubercular chemotherapy.A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR.Metabolism of thioamides by Ralstonia pickettii TA.Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrGComparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for isoniazid and ethionamide inactivationNew approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.Heme and I.Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosisMetabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse.Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3.Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis InhibitorsMetabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomesThe potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.Prodrugs for the treatment of neglected diseases.Recycling and refurbishing old antitubercular drugs: the encouraging case of inhibitors of mycolic acid biosynthesis.The TetR family of regulators.Mammalian designer cells: Engineering principles and biomedical applications.Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.4-Thio-carbamoylpyridin-1-ium iodideDrug metabolism by flavin-containing monooxygenases of human and mouse.Rapid detection of Mycobacterium tuberculosis resistance to second-line drugs by use of the manual mycobacterium growth indicator tube system.Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery.Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.
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P2860
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@ast
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@en
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@nl
type
label
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@ast
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@en
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@nl
prefLabel
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@ast
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@en
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@nl
P2093
P2860
P356
P1476
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase
@en
P2093
Alina Dykman
Paul R Ortiz de Montellano
Tommaso A Vannelli
P2860
P304
P356
10.1074/JBC.M110751200
P407
P577
2002-04-12T00:00:00Z