The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase
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Crystal structure of a Baeyer-Villiger monooxygenaseMechanism of thioamide drug action against tuberculosis and leprosyStrategies for potentiation of ethionamide and folate antagonists against Mycobacterium tuberculosisCrystal Structure of Baeyer−Villiger Monooxygenase MtmOIV, the Key Enzyme of the Mithramycin Biosynthetic Pathway,EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targetsAn ethA-ethR-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo, which correlate with altered mycolic acid compositionUse of an electronic nose to diagnose Mycobacterium bovis infection in badgers and cattle.Trafficking pathways of mycolic acids: structures, origin, mechanism of formation, and storage form of mycobacteric acids.High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.EthA/R-Independent Killing of Mycobacterium tuberculosis by Ethionamide.Pseudomonad cyclopentadecanone monooxygenase displaying an uncommon spectrum of Baeyer-Villiger oxidations of cyclic ketonesThiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrGThe Origin and Evolution of Baeyer-Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases.Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosisBaeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis InhibitorsMetabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomesThe potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.Prodrugs for the treatment of neglected diseases.Challenges and opportunities in developing novel drugs for TB.The TetR family of regulators.Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery.Expanding the set of rhodococcal Baeyer-Villiger monooxygenases by high-throughput cloning, expression and substrate screening.Escherichia coli Overexpressing a Baeyer-Villiger Monooxygenase from Acinetobacter radioresistens Becomes Resistant to Imipenem.Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.Cloning and characterization of the Type I Baeyer-Villiger monooxygenase from Leptospira biflexa.Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria.Identification of a novel Baeyer-Villiger monooxygenase from Acinetobacter radioresistens: close relationship to the Mycobacterium tuberculosis prodrug activator EtaA.Novel acetone metabolism in a propane-utilizing bacterium, Gordonia sp. strain TY-5.Ethionamide biomimetic activation and an unprecedented mechanism for its conversion into active and non-active metabolites.Update of Antitubercular Prodrugs from a Molecular Perspective: Mechanisms of Action, Bioactivation Pathways, and Associated Resistance.
P2860
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P2860
The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase
description
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2004
@ast
im Januar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/01/30)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/01/30)
@nl
наукова стаття, опублікована в січні 2004
@uk
name
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@ast
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@en
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@nl
type
label
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@ast
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@en
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@nl
prefLabel
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@ast
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@en
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@nl
P2093
P2860
P356
P1476
The prodrug activator EtaA fro ...... Baeyer-Villiger monooxygenase
@en
P2093
Annelies J. Heidekamp
Dick B. Janssen
Marco W. Fraaije
Nanne M. Kamerbeek
Riccardo Fortin
P2860
P304
P356
10.1074/JBC.M307770200
P407
P577
2004-01-30T00:00:00Z