Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site
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Modulation of xenobiotic receptors by steroidsTargeting xenobiotic receptors PXR and CAR in human diseasesInsights into CYP2B6-mediated drug-drug interactionsGene variants in noncoding regions and their possible consequences.Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).The transcriptional regulation of the human CYP2C genesHepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytesRetinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver.Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Cell-based systems to assess nuclear receptor activation and their use in drug development.CYP2B6: new insights into a historically overlooked cytochrome P450 isozymeNCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genesMed25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression.Drug-activated nuclear receptors CAR and PXR.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.PPARα as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds.Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liverPXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Role of CAR and PXR in xenobiotic sensing and metabolism.Novel CYP2C9 promoter variants and assessment of their impact on gene expression.Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alphaSignaling control of the constitutive androstane receptor (CAR)Cytochrome P450 2C9-CYP2C9.Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids.Nonviral gene transfer as a tool for studying transcription regulation of xenobiotic metabolizing enzymes.Nuclear hormone receptors PXR and CAR and metabolic diseases.Regulation of gene expression by CAR: an update.Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.Nigramide J is a novel potent inverse agonist of the human constitutive androstane receptor.Upregulation of human CYP2C9 expression by Bisphenol A via estrogen receptor alpha (ERα) and Med25.A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene.The influence of ethnicity on warfarin dosage requirement.LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver.Pharmacogenomics of CYP2C9: Functional and Clinical Considerations.Constitutive expression and phenobarbital modulation of drug metabolizing enzymes and related nuclear receptors in cattle liver and extra-hepatic tissues.
P2860
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P2860
Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Regulation of human CYP2C9 by ...... y of a new distal binding site
@ast
Regulation of human CYP2C9 by ...... y of a new distal binding site
@en
Regulation of human CYP2C9 by ...... y of a new distal binding site
@nl
type
label
Regulation of human CYP2C9 by ...... y of a new distal binding site
@ast
Regulation of human CYP2C9 by ...... y of a new distal binding site
@en
Regulation of human CYP2C9 by ...... y of a new distal binding site
@nl
prefLabel
Regulation of human CYP2C9 by ...... y of a new distal binding site
@ast
Regulation of human CYP2C9 by ...... y of a new distal binding site
@en
Regulation of human CYP2C9 by ...... y of a new distal binding site
@nl
P2093
P3181
P356
P1476
Regulation of human CYP2C9 by ...... y of a new distal binding site
@en
P2093
Edward L LeCluyse
Joyce A Goldstein
Masahiko Negishi
Stephen S Ferguson
P304
P3181
P356
10.1124/MOL.62.3.737
P407
P577
2002-09-01T00:00:00Z