A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.
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Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptorRoles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.Insights into CYP2B6-mediated drug-drug interactionsInduction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytesAMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell lineGenome-wide discovery of drug-dependent human liver regulatory elementsTransactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) ActivationPredictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals.Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Evolutionary history and functional characterization of the amphibian xenosensor CAR.Dietary flavonoids activate the constitutive androstane receptor (CAR).Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducersCAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Synergistically enhanced CYP2B6 inducibility between a polymorphic mutation in CYP2B6 promoter and pregnane X receptor activation.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium FerulateCYP2B6: new insights into a historically overlooked cytochrome P450 isozymeCarboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor.Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor.SLC13A5 is a novel transcriptional target of the pregnane X receptor and sensitizes drug-induced steatosis in human liver.Multi-species analyses of direct activators of the constitutive androstane receptor.Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structureCINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.Transcriptional Regulation of CYP3A4/2B6/2C9 Mediated via Nuclear Receptor PXR by Helicid and Its MetabolitesQuantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.Small-molecule modulators of the constitutive androstane receptor.An insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism.Small-molecule modulators of PXR and CAR.Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells.The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences.Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening.Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoformsAntimycotic drug discovery in the age of genomics.Pharmacogene regulatory elements: from discovery to applications
P2860
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P2860
A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
A novel distal enhancer module ...... ion of CYP2B6 gene expression.
@en
A novel distal enhancer module ...... ion of CYP2B6 gene expression.
@nl
type
label
A novel distal enhancer module ...... ion of CYP2B6 gene expression.
@en
A novel distal enhancer module ...... ion of CYP2B6 gene expression.
@nl
prefLabel
A novel distal enhancer module ...... ion of CYP2B6 gene expression.
@en
A novel distal enhancer module ...... ion of CYP2B6 gene expression.
@nl
P2093
P2860
P356
P1476
A novel distal enhancer module ...... ion of CYP2B6 gene expression.
@en
P2093
Hongbing Wang
Masahiko Negishi
Rick Moore
Stephanie Faucette
Stephen Ferguson
Tatsuya Sueyoshi
P2860
P304
14146-14152
P356
10.1074/JBC.M212482200
P407
P577
2003-02-05T00:00:00Z