Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure - Wikidata - wikimedia - TriplyDB

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

http://www.wikidata.org/entity/Q28222762

about

Side effect profile prediction - early addressing of big pharma's worst nightmare Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies Inroads to predict in vivo toxicology-an introduction to the eTOX Project Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases Target prediction utilising negative bioactivity data covering large chemical space In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps)Network neighbors of drug targets contribute to drug side-effect similarity Comparability of mixed IC₅₀ data - a statistical analysis Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models Looking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action Computational prediction and validation of an expert's evaluation of chemical probes A side effect resource to capture phenotypic effects of drugs Systematic identification of proteins that elicit drug side effects Large-scale prediction of drug-target relationships Application of the 4D fingerprint method with a robust scoring function for scaffold-hopping and drug repurposing strategies.Comparison of ultra-fast 2D and 3D ligand and target descriptors for side effect prediction and network analysis in polypharmacology.How promiscuous are pharmaceutically relevant compounds? A data-driven assessment.Finding the targets of a drug by integration of gene expression data with a protein interaction network.A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities Fusing dual-event data sets for Mycobacterium tuberculosis machine learning models and their evaluation.Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosis Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data.Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014-2015).Exploiting Pharmacological Similarity to Identify Safety Concerns - Listen to What the Data Tells You.Big Data Mining and Adverse Event Pattern Analysis in Clinical Drug Trials Prospective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases.Kinase inhibition-related adverse events predicted from in vitro kinome and clinical trial data.A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization Physicochemical drug properties associated with in vivo toxicological outcomes: a review.Recent trends and observations in the design of high-quality screening collections.Predicting adverse drug reactions using publicly available PubChem BioAssay data Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery?Computational methods for early predictive safety assessment from biological and chemical data.Drug repositioning using in silico compound profiling.Predicting adverse side effects of drugs The chemical basis of pharmacology.

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P2860

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

http://www.wikidata.org/entity/Q28222762

description

2007 nî lūn-bûn

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2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2007 թվականի հունիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Analysis of pharmacology data ...... ffects from chemical structure

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Analysis of pharmacology data ...... ffects from chemical structure

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Analysis of pharmacology data ...... ffects from chemical structure

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type

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Analysis of pharmacology data ...... ffects from chemical structure

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Analysis of pharmacology data ...... ffects from chemical structure

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Analysis of pharmacology data ...... ffects from chemical structure

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Analysis of pharmacology data ...... ffects from chemical structure

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Analysis of pharmacology data ...... ffects from chemical structure

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Analysis of pharmacology data ...... ffects from chemical structure

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Analysis of pharmacology data ...... ffects from chemical structure

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Jacques Hamon

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John W Davies

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Kamal Azzaoui

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Laszlo Urban

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Meir Glick

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Steven Whitebread

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861-873

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scholarly article

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889051

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10.1002/CMDC.200700026

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6

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2

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Jeremy L. Jenkins

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2007-06-01T00:00:00Z

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6353559

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17477341

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