In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators
about
Chapter 7: PharmacogenomicsHarvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactomeA multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homologyIdentifying unexpected therapeutic targets via chemical-protein interactomeBinding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurementsDrug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitorsFINDSITE: a threading-based approach to ligand homology modelingDrug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosisThe Mycobacterium tuberculosis drugome and its polypharmacological implicationsExploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case studySystematic drug repositioning based on clinical side-effectsAssessing drug target association using semantic linked dataAutomatic filtering and substantiation of drug safety signalsDrug Promiscuity in PDB: Protein Binding Site Similarity Is KeyDirect, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handlingLarge-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug RepurposingImproved genome-scale multi-target virtual screening via a novel collaborative filtering approach to cold-start problem.Systematic identification of proteins that elicit drug side effectsDetecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments.BioGPS: navigating biological space to predict polypharmacology, off-targeting, and selectivity.SMAP-WS: a parallel web service for structural proteome-wide ligand-binding site comparison.Toward a "structural BLAST": using structural relationships to infer function.Protein pockets: inventory, shape, and comparisonProviding data science support for systems pharmacology and its implications to drug discoveryUnderstanding nuclear receptors using computational methods.DDI-CPI, a server that predicts drug-drug interactions through implementing the chemical-protein interactome.Predicting adverse drug reactions using publicly available PubChem BioAssay dataMolecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association.The chemical basis of pharmacology.Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease.Structure-based systems biology for analyzing off-target bindingLife beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discoveryOpportunities for the replacement of animals in the study of nausea and vomitingIs protein classification necessary? Toward alternative approaches to function annotation.Chemical-protein interactome and its application in off-target identification.Drug repositioning for orphan diseases.Exploiting structural information for drug-target assessment.Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effectsTargeting the off-targets: a computational bioinformatics approach to understanding the polypharmacology of nelfinavir.
P2860
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P2860
In silico elucidation of the molecular mechanism defining the adverse effect of selective estrogen receptor modulators
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
In silico elucidation of the m ...... e estrogen receptor modulators
@ast
In silico elucidation of the m ...... e estrogen receptor modulators
@en
In silico elucidation of the m ...... e estrogen receptor modulators
@nl
type
label
In silico elucidation of the m ...... e estrogen receptor modulators
@ast
In silico elucidation of the m ...... e estrogen receptor modulators
@en
In silico elucidation of the m ...... e estrogen receptor modulators
@nl
prefLabel
In silico elucidation of the m ...... e estrogen receptor modulators
@ast
In silico elucidation of the m ...... e estrogen receptor modulators
@en
In silico elucidation of the m ...... e estrogen receptor modulators
@nl
P2860
P3181
P1476
In silico elucidation of the m ...... e estrogen receptor modulators
@en
P2093
P2860
P3181
P356
10.1371/JOURNAL.PCBI.0030217
P407
P577
2007-11-01T00:00:00Z