Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells - Wikidata - wikimedia - TriplyDB

Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells

Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells

http://www.wikidata.org/entity/Q28238141

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siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands N-Arachidonyl glycine does not activate G protein-coupled receptor 18 signaling via canonical pathways Endocannabinoids as Guardians of Metastasis Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis The cannabinoid acids, analogs and endogenous counterparts The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18 CB2 receptor activation inhibits melanoma cell transmigration through the blood-brain barrier.A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats.A GPR18-based signalling system regulates IOP in murine eye.Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice.Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor.GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation.Cannabinoid receptors: nomenclature and pharmacological principles So what do we call GPR18 now?Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner.Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor.A potential role for GPR55 in gastrointestinal functions N-Arachidonoyl glycine suppresses Na⁺/Ca²⁺ exchanger-mediated Ca²⁺ entry into endothelial cells and activates BK(Ca) channels independently of GPCRs.Brain levels of prostaglandins, endocannabinoids, and related lipids are affected by mating strategies.The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries.Intercellular Lipid Mediators and GPCR Drug Discovery Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism.The novel endocannabinoid receptor GPR18 is expressed in the rostral ventrolateral medulla and exerts tonic restraining influence on blood pressure.Molecular Targets of the Phytocannabinoids: A Complex Picture.GPR18 in microglia: implications for the CNS and endocannabinoid system signalling Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands.Endothelial atypical cannabinoid receptor: do we have enough evidence?New approaches in the design and development of cannabinoid receptor ligands: multifunctional and bivalent compounds.The evolving role of the endocannabinoid system in gynaecological cancer.G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction.The Clinical Significance of Endocannabinoids in Endometriosis Pain Management.Resveratrol protects from lipopolysaccharide-induced inflammation in the uterus and prevents experimental preterm birth.Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies.Molecular Pharmacology of Phytocannabinoids.

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Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells

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Heather B Bradshaw

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P2860

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

Endometriosis and infertility

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

Novel cannabinoid receptors

The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways

Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia

(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability

Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂

Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists

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