Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1) - Wikidata - wikimedia - TriplyDB

Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)

Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)

http://www.wikidata.org/entity/Q28238959

about

NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation Dcas supports cell polarization and cell-cell adhesion complexes in development MICAL, a novel CasL interacting molecule, associates with vimentin Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.The docking protein HEF1 is an apoptotic mediator at focal adhesion sites A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1 CAS proteins in normal and pathological cell growth control Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle VHL inactivation induces HEF1 and Aurora kinase A SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.The carboxyl-terminal SH3 domain of the mammalian adaptor CrkII promotes internalization of Listeria monocytogenes through activation of host phosphoinositide 3-kinase.Uncoupling Crk signal transduction by Pseudomonas exoenzyme T.The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration.Involvement of the adapter protein CRKL in integrin-mediated adhesion.Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells.A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes.Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl.Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein.Cbl: many adaptations to regulate protein tyrosine kinases.Beyond the RING: CBL proteins as multivalent adapters.BCR-ABL as a target for novel therapeutic interventions.On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts.Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells.Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML.Proteomic responses to elevated ocean temperature in ovaries of the ascidian Ciona intestinalis.Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins Abi1 gene silencing by short hairpin RNA impairs Bcr-Abl-induced cell adhesion and migration in vitro and leukemogenesis in vivo.Escherichia coli virulence protein NleH1 interaction with the v-Crk sarcoma virus CT10 oncogene-like protein (CRKL) governs NleH1 inhibition of the ribosomal protein S3 (RPS3)/nuclear factor κB (NF-κB) pathway.A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.Estrogen-Initiated Protein Interactomes During Embryo Implantation.Signal Transduction by the Philadelphia Chromosome-encoded BCR/ABL Oncoproteins: Therapeutic Implications for Chronic Myeloid Leukemia and Philadelphia-positive Acute Lymphoblastic Leukemia.KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570.Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils.Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk.Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.

P2860

Q21135305-D630B6C7-C5AB-4823-A974-1FEEFF4D0B8F Q21136167-37447E02-F001-4B8E-AB6C-2A492EB3FDCD Q24292258-148128E8-7B3B-4E82-B17E-7E47A95F901C Q24315726-47DC4725-50E7-45A1-8DFA-9E9BB0F3F163 Q24553123-C6291C2B-745B-4365-8FD5-D0BA8057FCE3 Q24595443-B383C6F8-A0C9-40E2-9331-DEF05A78C5DB Q24630247-D8AF144E-1387-4E03-B466-56C7EF3BF635 Q28085339-676F5504-A261-4286-8DBC-7A1CE991A5E9 Q28142663-1D3BB29B-9F60-4FD0-8C20-E5193A2A747A Q28218641-21770801-BAE5-4CB0-BB2E-AC77B7968CCA Q28241105-F4267EDD-94ED-4AAC-A843-B70071837A63 Q28294037-53FC7A71-ADDE-4CF1-8FB7-57080EA4D3D5 Q28592496-E570FFE7-B99B-43BD-BBBF-3C90C69ED02A Q30010476-3507F1B1-B8DC-405E-869D-64619D3CAA1B Q30157772-DD45BF36-62EB-4498-8F13-4C3888CE3936 Q30160151-A2BBBDE2-0906-4E55-B1B1-0FABC61D1042 Q30175281-01C1958A-056D-40B1-922B-9686E61CA7FB Q30175432-DDB8500B-DC6D-450C-BDCF-237B67D9D122 Q30176087-7CB016F9-6630-4699-A589-5A64467E9300 Q30176126-2CF9C783-A132-447A-BD3C-03BA3CC1946F Q31672728-A69B3818-C47E-4DCD-B099-5F6C2868D1B1 Q33756407-5A308784-B56D-49A2-89BA-80FC7E346EC5 Q34205572-167D75BE-B88C-40B8-9DF3-18AFB81D9117 Q34405560-FEA2411C-1897-413A-B659-F5B85F99A959 Q34568971-FDE6BF8C-BF74-4898-BFD7-EBFEEDD28DFF Q35854970-3891593E-8603-4220-AA7E-7EE22B3FA18E Q36086815-51F60953-D003-4D31-A209-C874D74CB683 Q36286872-D3205938-FEC8-4245-9872-1A0CC516E149 Q36370775-2DA416DA-E414-401E-82B9-67AE23286136 Q36674591-8FF2D09C-18F7-4E01-93F3-76D312E76068 Q36857570-955E3968-5252-4954-82E9-9725927D7038 Q37348920-CE8F9522-0B24-4AA4-9A16-24C1CBF364C5 Q38334944-DA7F653A-5E72-4129-B6E3-D8DACE2007BF Q38667869-C5520BB9-DA54-4FB3-9AEA-A7E0E7BEEE90 Q38896241-FB29ACB1-9E07-4A2D-9B86-D22475AD975F Q39193013-7244D5C9-8404-4C1A-912B-35E316CD1E2A Q39984335-40D99BCE-94C4-4924-9168-ABFB1072FB58 Q42820265-E0B9386B-4708-4966-B307-BA25010EB1BF Q42909224-A87FF8D4-3675-4963-93D0-677953C654D4 Q43982351-74BB91FF-3855-4622-88C9-5C6AEBDAFE7E

P2860

Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)

http://www.wikidata.org/entity/Q28238959

description

1997 nî lūn-bûn

@nan

1997 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի մայիսին հրատարակված գիտական հոդված

@hy

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

name

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@ast

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@en

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@nl

type

label

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@ast

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@en

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@nl

prefLabel

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@ast

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@en

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@nl

P1433

Q28238959-1F3BBCCE-7669-4DAB-B877-38B9D5ADA462

P1476

Q28238959-237957CF-16D8-4597-8023-9E4E80883991

P2093

Q28238959-00AB6DE1-A3EB-4207-9181-B5BC0DA7845A

Q28238959-097DB0CA-B5C5-4ED1-A377-C4B29C84BBFC

Q28238959-69B0FD1D-B112-4118-A930-271C9DB26A6E

Q28238959-716CC3F4-A96F-4D8E-BC8E-149ADAACAFED

Q28238959-78DDAA5C-6F94-4D42-85AD-85C4BD426381

Q28238959-946E657F-7603-463D-8834-5538C0FD5647

Q28238959-95F7DCBF-FAC8-43DA-992D-9D24C6951B72

Q28238959-FCD52138-3BE2-4187-9EFA-CCA6F0EC0F67

P2860

Q28238959-064CD761-D62B-4103-8646-CBF29DBE628B

Q28238959-1C054D54-7211-4EFE-B876-1E410299D717

Q28238959-21E4B26A-C2A1-407C-90D1-4C536E4CBEA4

Q28238959-25973C31-5A63-4F81-8A5F-CB2D1C32A768

Q28238959-41079E9F-8F49-4B21-B942-916FDED417BA

Q28238959-464FC23D-4F2F-4DC1-BABF-E154C5A4C8CE

Q28238959-4755BC97-CED6-404F-9693-10E5842F3A90

Q28238959-49768C5F-7C73-4114-88EB-DE896BE51ECF

Q28238959-537BA54C-E85D-4682-AF03-211850EEB37C

Q28238959-58AADD20-C325-4DA9-B601-D63806A6C850

P304

Q28238959-7774B302-B7BB-4D35-BFA8-2F5D896846DE

P31

Q28238959-B2CBB556-8FF8-4BFE-94FE-A847CDDA3583

P356

Q28238959-448C0102-30CE-4FE0-ABC0-3295573166F7

P407

Q28238959-4A4CE37D-5CF5-46A8-8ADF-BDA3219D91A2

P433

Q28238959-CBBC2DA7-7562-48EB-92F9-DA3212E160C9

P478

Q28238959-3C83EC55-CBDC-4965-B06B-C97B8E6A07EB

P577

Q28238959-FA45C19E-D520-4F66-AA3F-7C05EFFBD5B3

P5875

Q28238959-CA6A57A5-5BBE-449D-8B8D-DCF24179DF5F

P698

Q28238959-CA97E48A-B085-4284-BCAC-A996956AC626

P356

JBC.272.22.14320

P1433

Journal of Biological Chemistry

P1476

Differential signaling after b ...... KL to p120(CBL) and p110(HEF1)

@en

P2093

E A Golemis

http://www.w3.org/2001/XMLSchema#string

G Shrikhande

http://www.w3.org/2001/XMLSchema#string

J D Griffin

http://www.w3.org/2001/XMLSchema#string

M Sattler

http://www.w3.org/2001/XMLSchema#string

N Uemura

http://www.w3.org/2001/XMLSchema#string

R Salgia

http://www.w3.org/2001/XMLSchema#string

S F Law

http://www.w3.org/2001/XMLSchema#string

S Verma

http://www.w3.org/2001/XMLSchema#string

P2860

Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

Two species of human CRK cDNA encode proteins with distinct biological activities

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

Integrins: emerging paradigms of signal transduction

P304

14320-6

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.272.22.14320

http://www.w3.org/2001/XMLSchema#string

P407

P433

22

http://www.w3.org/2001/XMLSchema#string

P478

272

http://www.w3.org/2001/XMLSchema#string

P577

1997-05-30T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

14056701

http://www.w3.org/2001/XMLSchema#string

P698

9162067

http://www.w3.org/2001/XMLSchema#string