4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications
about
4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferationMammalian target of rapamycin: a central node of complex signaling cascadesThe mTOR signalling pathway in human cancerSignalling to eIF4E in cancerAmino acid management in cancerWhat a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathwayRegulation of translation initiation in eukaryotes: mechanisms and biological targetsNew hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stressPpargamma2 is a key driver of longevity in the mouse.EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors.Analysis of receptor tyrosine kinases (RTKs) and downstream pathways in chordomasPooling breast cancer datasets has a synergetic effect on classification performance and improves signature stabilityCold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activationExpression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells.Stabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation.Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancerExpression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal hornFisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells.Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail.Eukaryotic initiation factor 4F: a vulnerability of tumor cells.Activation of the MEK-S6 pathway in high-grade ovarian cancers.Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1.Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent.Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4FTargeting osteosarcoma.Requirement for the eIF4E binding proteins for the synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibitionTargeting the eIF4F translation initiation complex: a critical nexus for cancer development4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.EIF4EBP1 overexpression is associated with poor survival and disease progression in patients with hepatocellular carcinomaActivation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women.The synergistic inhibition of breast cancer proliferation by combined treatment with 4EGI-1 and MK2206Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.mLST8 Promotes mTOR-Mediated Tumor Progression.CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translationInsights into 4E-BP1 and p53 mediated regulation of accelerated cell senescencePrognostic significance of phosphorylated 4E-binding protein 1 in non-small cell lung cancer.Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation.4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.
P2860
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P2860
4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
4E-binding protein 1: a key mo ...... cer with clinical implications
@ast
4E-binding protein 1: a key mo ...... cer with clinical implications
@en
4E-binding protein 1: a key mo ...... cer with clinical implications
@nl
type
label
4E-binding protein 1: a key mo ...... cer with clinical implications
@ast
4E-binding protein 1: a key mo ...... cer with clinical implications
@en
4E-binding protein 1: a key mo ...... cer with clinical implications
@nl
prefLabel
4E-binding protein 1: a key mo ...... cer with clinical implications
@ast
4E-binding protein 1: a key mo ...... cer with clinical implications
@en
4E-binding protein 1: a key mo ...... cer with clinical implications
@nl
P2093
P50
P3181
P1433
P1476
4E-binding protein 1: a key mo ...... cer with clinical implications
@en
P2093
Berta Pons
Carmela Iglesias
Federico Rojo
José Baselga
Miriam Cuatrecasas
P304
P3181
P356
10.1158/0008-5472.CAN-07-0881
P407
P577
2007-08-01T00:00:00Z