Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F
about
Structural conservation of druggable hot spots in protein-protein interfacesTargeting translation initiation in breast cancerStructure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4GTargeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotideRegulation of cardiac expression of the diabetic marker microRNA miR-29Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegenerationViral and Cellular mRNA Translation in Coronavirus-Infected Cells.On the importance of composite protein multiple ligand interactions in protein pockets.A Fluorescence in Situ Hybridization Method To Quantify mRNA Translation by Visualizing Ribosome-mRNA Interactions in Single Cells.Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancerBlocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B.Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail.Eukaryotic initiation factor 4F: a vulnerability of tumor cells.Functional analysis of Kaposi's sarcoma-associated herpesvirus vFLIP expression reveals a new mode of IRES-mediated translation.Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopeciaAn eIF4E-interacting peptide induces cell death in cancer cell lines.Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblastsRequirement for the eIF4E binding proteins for the synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibitionTargeting survivin in cancer: novel drug development approaches.Targeting the eIF4F translation initiation complex: a critical nexus for cancer developmentRibosomal protein S19-binding domain provides insights into hantavirus nucleocapsid protein-mediated translation initiation mechanism.Murine norovirus 1 (MNV1) replication induces translational control of the host by regulating eIF4E activity during infectionThe E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.Switch from cap- to factorless IRES-dependent 0 and +1 frame translation during cellular stress and dicistrovirus infection.CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translationAlternative reading frame selection mediated by a tRNA-like domain of an internal ribosome entry siteEmerging therapeutics targeting mRNA translationLoss of tumor suppressor NF1 activates HSF1 to promote carcinogenesisTherapeutic interventions to disrupt the protein synthetic machinery in melanomaModifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A.Targeting translation dependence in cancerCap-dependent translation initiation factor eIF4E: an emerging anticancer drug target.Anti-oncogenic potential of the eIF4E-binding proteins.Translational control in cellular and developmental processes.Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation.Potential therapeutic applications of RNA cap analogs.Novel viral translation strategies.Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza.Computational solvent mapping in structure-based drug design.
P2860
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P2860
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@ast
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@en
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@nl
type
label
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@ast
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@en
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@nl
prefLabel
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@ast
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@en
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@nl
P2093
P2860
P356
P1476
Reversing chemoresistance by s ...... ation initiation complex eIF4F
@en
P2093
David R Hall
Francis Robert
Iestyn Lewis
Jerry Pelletier
Ray Dingledine
Regina Cencic
P2860
P304
P356
10.1073/PNAS.1011477108
P407
P50
P577
2010-12-29T00:00:00Z