Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates - Wikidata - wikimedia - TriplyDB

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

http://www.wikidata.org/entity/Q28243550

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Transposon-based screens for cancer gene discovery in mouse models A transposon and transposase system for human application Comparative analysis of transposable element vector systems in human cells The Sleeping Beauty transposon system: a non-viral vector for gene therapy Neuroprotective therapies in glaucoma: II. Genetic nanotechnology tools The gene therapy journey for hemophilia: are we there yet?A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19 Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine Unique alterations of an ultraconserved non-coding element in the 3'UTR of ZIC2 in holoprosencephaly β-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model Breeding based remobilization of Tol2 transposon in Xenopus tropicalis Genotype-independent transmission of transgenic fluorophore protein by boar spermatozoa In vivo screening for secreted proteins that modulate glucose handling identifies interleukin-6 family members as potent hypoglycemic agents Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome Differentiation of Induced Pluripotent Stem Cells to Lentoid Bodies Expressing a Lens Cell-Specific Fluorescent Reporter The processing of repetitive extragenic palindromes: the structure of a repetitive extragenic palindrome bound to its associated nuclease NMR structural analysis ofSleeping Beautytransposase binding to DNA Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives A Broad Range of Dose Optima Achieve High-level, Long-term Gene Expression After Hydrodynamic Delivery of Sleeping Beauty Transposons Using Hyperactive SB100x Transposase Gene therapy for hemophilia Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice Driving DNA transposition by lentiviral protein transduction DNA transposon-based gene vehicles - scenes from an evolutionary drive Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin Genome-wide target profiling of piggyBac and Tol2 in HEK 293: pros and cons for gene discovery and gene therapy A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos DNA transposons: nature and applications in genomics Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation Prokaryotic expression and purification of soluble goldfish Tgf2 transposase with transposition activity.Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice.Ultrasound directs a transposase system for durable hepatic gene delivery in mice Hyperactive self-inactivating piggyBac for transposase-enhanced pronuclear microinjection transgenesis.Sleeping beauty system to redirect T-cell specificity for human applications.Human satellite cells have regenerative capacity and are genetically manipulable.Dynamics of transposable elements: towards a community ecology of the genome.Directed evolution of recombinase specificity by split gene reassembly Recent advances in genetics of the spontaneously hypertensive rat.High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene Novel strong tissue specific promoter for gene expression in human germ cells.Multiplexed transposon-mediated stable gene transfer in human cells

P2860

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P2860

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

http://www.wikidata.org/entity/Q28243550

description

2009 nî lūn-bûn

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2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2009 թվականի հունիսին հրատարակված գիտական հոդված

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2009年の論文

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Molecular evolution of a novel ...... e gene transfer in vertebrates

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Molecular evolution of a novel ...... e gene transfer in vertebrates

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Molecular evolution of a novel ...... e gene transfer in vertebrates

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Molecular evolution of a novel ...... e gene transfer in vertebrates

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Molecular evolution of a novel ...... e gene transfer in vertebrates

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Molecular evolution of a novel ...... e gene transfer in vertebrates

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Molecular evolution of a novel ...... e gene transfer in vertebrates

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Molecular evolution of a novel ...... e gene transfer in vertebrates

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Molecular evolution of a novel ...... e gene transfer in vertebrates

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Abel Acosta-Sanchez

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Andrea Schmitt

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Boris Jerchow

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Bradley Fletcher

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Conny Gysemans

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Csaba Miskey

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Diana Pryputniewicz

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Ermira Samara-Kuko

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Eyayu Belay

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Janka Matrai

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P2860

Mutational analysis of the N-terminal DNA-binding domain of sleeping beauty transposase: critical residues for DNA binding and hyperactivity in mammalian cells

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice

Shielding of sleeping beauty DNA transposon-delivered transgene cassettes by heterologous insulators in early embryonal cells

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

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188946

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10.1038/NG.343

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24398608

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1034767313

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19412179

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