Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit - Wikidata - wikimedia - TriplyDB

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

http://www.wikidata.org/entity/Q28244567

about

Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)The role of androgens in metabolism, obesity, and diabetes in males and females Pharmacology of manipulating lean body mass MicroRNAs are mediators of androgen action in prostate and muscle Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors.Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.Identification of selected in vitro generated phase-I metabolites of the steroidal selective androgen receptor modulator MK-0773 for doping control purposes.Male osteoporosis and androgenic therapy: from testosterone to SARMs.Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978.Therapies for musculoskeletal disease: can we treat two birds with one stone?Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial.Hormonal approaches to male contraception.Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet.An update on male hypogonadism therapy.Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome Structural basis for computational screening of non-steroidal androgen receptor ligands.Deciphering the selective androgen receptor modulators paradigm.Estrogens and Androgens in Skeletal Physiology and Pathophysiology.Complex modulation of androgen responsive gene expression by methoxyacetic acid.Anabolic effect of plant brassinosteroid.Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer Methoxychalcone inhibitors of androgen receptor translocation and function.Structure-based virtual screening and identification of a novel androgen receptor antagonist.Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues The androgen receptor and its use in biological assays: looking toward effect-based testing and its applications.Local delivery of a selective androgen receptor modulator failed as an anabolic agent in a rat bone marrow ablation model Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male.Does ethnicity matter in male hormonal contraceptive efficacy?Recent patent trends in the field of progesterone receptor agonists and modulators.Androgen effects on skeletal muscle: implications for the development and management of frailty.Selective androgen receptor modulators for the treatment of late onset male hypogonadism.Male hormonal contraception: potential risks and benefits.Improving selective androgen receptor modulator discovery and preclinical evaluation.Sex hormones and skeletal muscle weakness.Androgen receptor modulators: a marriage of chemistry and biology.Integrated therapies for osteoporosis and sarcopenia: from signaling pathways to clinical trials.Pharmacologic Options for the Treatment of Sarcopenia.

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P2860

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit

http://www.wikidata.org/entity/Q28244567

description

2009 nî lūn-bûn

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2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2009年の論文

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Journal of Medicinal Chemistry

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Amanda Jones

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Casey E Bohl

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Christopher C Coss

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Dong Jin Hwang

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Duane D Miller

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James T Dalton

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Michael L Mohler

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Ramesh Narayanan

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Yali He

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