Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase
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Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functionsLongitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypesWhat a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations.The human paraoxonase gene cluster as a target in the treatment of atherosclerosisHydrophobicity and charge shape cellular metabolite concentrationsModulation of paraoxonases during infectious diseases and its potential impact on atherosclerosisStructural and mutational analyses of Drp35 from Staphylococcus aureus: a possible mechanism for its lactonase activityRapid determination of hydrogen positions and protonation states of diisopropyl fluorophosphatase by joint neutron and X-ray diffraction refinementComputational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysisSwitching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263TrpParaoxonases as potential antibiofilm agents: their relationship with quorum-sensing signals in Gram-negative bacteriaHuman paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological rolesOne enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activityReverse evolution leads to genotypic incompatibility despite functional and active site convergenceParaoxonase 1 and homocysteine metabolism.Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidaseIn vivo administration of BL-3050: highly stable engineered PON1-HDL complexesIncorporating Synthetic Oligonucleotides via Gene Reassembly (ISOR): a versatile tool for generating targeted libraries.Hydrolysis of DFP and the nerve agent (S)-sarin by DFPase proceeds along two different reaction pathways: implications for engineering bioscavengers.Hyperthermophilic phosphotriesterases/lactonases for the environment and human health.Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanalA systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes.VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results.The level of DING proteins is increased in HIV-infected patients: in vitro and in vivo studies.Expression of human paraoxonase 1 decreases superoxide levels and alters bacterial colonization in the gut of Drosophila melanogaster.Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.Inter-kingdom signalling: communication between bacteria and their hosts.Exploring the role of paraoxonases in the pathogenesis of coronary artery disease: a systematic review.Effect of PON1 on dichlorvos toxicokinetics.Mechanistic Insights into the Hydrolysis of Organophosphorus Compounds by Paraoxonase-1: Exploring the Limits of Substrate Tolerance in a Promiscuous Enzyme.Active site loop conformation regulates promiscuous activity in a lactonase from Geobacillus kaustophilus HTA426Serum paraoxonase 1 (PON1) measurement: an update.Species differences in paraoxonase mediated hydrolysis of several organophosphorus insecticide metabolites.Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease.An in vivo metabolic approach for deciphering the product specificity of glycerate kinase proves that both E. coli's glycerate kinases generate 2-phosphoglycerate.Assessing the prediction fidelity of ancestral reconstruction by a library approach.Relationship between paraoxonase and homocysteine: crossroads of oxidative diseases.Toward Understanding the Catalytic Mechanism of Human Paraoxonase 1: Site-Specific Mutagenesis at Position 192Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.Promiscuity in the Enzymatic Catalysis of Phosphate and Sulfate Transfer.
P2860
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P2860
Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structure-reactivity studies o ...... s native activity is lactonase
@ast
Structure-reactivity studies o ...... s native activity is lactonase
@en
Structure-reactivity studies o ...... s native activity is lactonase
@nl
type
label
Structure-reactivity studies o ...... s native activity is lactonase
@ast
Structure-reactivity studies o ...... s native activity is lactonase
@en
Structure-reactivity studies o ...... s native activity is lactonase
@nl
prefLabel
Structure-reactivity studies o ...... s native activity is lactonase
@ast
Structure-reactivity studies o ...... s native activity is lactonase
@en
Structure-reactivity studies o ...... s native activity is lactonase
@nl
P3181
P356
P1433
P1476
Structure-reactivity studies o ...... s native activity is lactonase
@en
P2093
Dan S Tawfik
Olga Khersonsky
P304
P3181
P356
10.1021/BI047440D
P407
P577
2005-04-26T00:00:00Z