Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis - Wikidata - wikimedia - TriplyDB

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

http://www.wikidata.org/entity/Q27677060

about

Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymes Catalytic efficiency of designed catalytic proteins Protein design: toward functional metalloenzymes Principles for designing ideal protein structures Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template In Vitro and Cellular Self-Assembly of a Zn-Binding Protein Cryptand via Templated Disulfide Bonds A protein engineered to bind uranyl selectively and with femtomolar affinity Dynamics and hydration explain failed functional transformation in dehalogenase design Advances in the directed evolution of proteins.Rational design of heterodimeric protein using domain swapping for myoglobin A designed supramolecular protein assembly with in vivo enzymatic activity X-ray crystallographic validation of structure predictions used in computational design for protein stabilization Directed evolution of artificial metalloenzymes for in vivo metathesis Kinetic Characterization of 100 Glycoside Hydrolase Mutants Enables the Discovery of Structural Features Correlated with Kinetic Constants Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure Combined covalent-electrostatic model of hydrogen bonding improves structure prediction with Rosetta Protein folding and de novo protein design for biotechnological applications Designing hydrolytic zinc metalloenzymes Computational approaches for rational design of proteins with novel functionalities Computational protein engineering: bridging the gap between rational design and laboratory evolution.Achievements and Challenges in Computational Protein Design.Structural principles for computational and de novo design of 4Fe-4S metalloproteins.Influence of active site location on catalytic activity in de novo-designed zinc metalloenzymes.Comparison of designed and randomly generated catalysts for simple chemical reactions Binding pocket optimization by computational protein design.Interplay of physics and evolution in the likely origin of protein biochemical function OptZyme: computational enzyme redesign using transition state analogues Enantioselective enzymes by computational design and in silico screening.Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering.Computational strategies for the design of new enzymatic functions Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.Toward high-resolution computational design of the structure and function of helical membrane proteins Designing functional metalloproteins: from structural to catalytic metal sites.Biotinylated Rh(III) complexes in engineered streptavidin for accelerated asymmetric C-H activation TSTMP: target selection for structural genomics of human transmembrane proteins.The effect of the hydrophobic environment on the retro-aldol reaction: comparison to a computationally-designed enzyme.Upgrading protein synthesis for synthetic biology.A highly efficient cocaine-detoxifying enzyme obtained by computational design.Artificial metalloenzymes as catalysts in stereoselective Diels-Alder reactions.Constructing manmade enzymes for oxygen activation.

P2860

Q24289386-A43F1901-C7FA-4104-B9D2-9C71764B5E05 Q26859933-173B8F06-C94A-44B8-88AE-405B07C8802A Q26866201-7127E848-B1A4-4218-8CC9-0B795940E203 Q27675027-3BF1711A-2C4E-40D7-A06C-A0EA143BFFDE Q27679003-936EC733-29E6-4A47-8678-5C7A094860EA Q27679319-7E93733D-1D1E-4513-BD5D-4D11444BF828 Q27689318-2E82C552-AB76-47D1-85AE-F79FDB51A80A Q27690038-7D2DE8CB-50F2-4D59-AF0E-394994D7B244 Q27692562-2E0714FF-EF51-4ECC-9076-118EAFE2AEAE Q27696139-68F08E0A-A341-4BDF-A72E-7A1C6A9658B5 Q27696882-FD6D628B-97A4-4D9F-B553-91E0E0D66D25 Q27698099-C062FBAD-20D5-409F-A473-06CFAFFAFDE0 Q27727857-D04E6857-8C74-4295-B832-AF92540D76C9 Q28552915-AC6AA08B-BC82-423F-9BED-094151B7A1DA Q28830531-767C064F-E051-47A6-92BC-6D67C6E7F3F0 Q28914716-C5084ECC-76AE-4EB7-AA61-F661E6B535FD Q30355936-355CAB9E-7C13-41E1-B3A6-0CF27499AF9B Q30358793-926657B0-4EA4-4A57-9594-6E89D6FE4542 Q30360853-205AA905-6765-42C5-B0A5-9EFEEB0FDA99 Q30394571-DA79693A-B460-4D54-B2BF-55BF542871F9 Q30395939-4CC35F32-C855-4DD2-8390-2D9C55B24671 Q33558989-AD79D155-1EFC-48FC-927A-C3EE16B1C4DF Q34334474-08107D98-C119-45AD-9651-215FC5F92113 Q34343397-98899498-171C-4061-904D-3AD2B468B041 Q34540792-502F6389-EC2E-42FC-BC19-727A58F31927 Q34729649-F86EB5FF-09BF-412B-9115-3867A26D1598 Q35014423-6EF6D159-3447-41EB-8313-701D8395511E Q35555046-D9FA1457-0C00-4AFF-B49E-A9ABB526511A Q35947597-58E1EB53-66C0-42C6-9100-F7C62EA58406 Q36011420-BE9B4323-1E07-41F4-8911-5A575B75A417 Q36270529-A9D27A1B-C550-4174-85C3-B5CDF48CFDA6 Q37128527-33228C37-C121-4FB7-A8D3-50580A7962E1 Q37131196-4A1FFBC4-6D80-4733-AF24-0B5566AF3D31 Q37286557-2C576784-898A-49E0-B6D0-D9BEC7AC791E Q37557027-51004006-32E9-475E-9D46-6FF5E8268455 Q37573934-F4462F2A-7191-4101-BA88-34C4F712B44C Q37683505-4B6F72C1-DD1E-4FBD-BE70-CE00670CF294 Q37718522-F7F5C908-3D9E-43A8-899A-29AC9139F977 Q38019867-2BEFD3D7-8FD3-47BC-B89D-6496D7CF4C1E Q38053061-5D0B64A1-1CB3-49A7-9BFE-03FBACE8F976

P2860

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

http://www.wikidata.org/entity/Q27677060

description

2012 nî lūn-bûn

@nan

2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@ast

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@en

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@nl

type

label

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@ast

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@en

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@nl

prefLabel

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@ast

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@en

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@nl

P1433

Q27677060-4DF6A1F4-C205-4774-B9AB-045B962E329E

P1476

Q27677060-32054EC3-D831-4D98-94AC-B833D01DD55B

P2093

Q27677060-256FC676-4676-4519-8993-13FD53D4A8E6

Q27677060-3F5D14A8-E657-49E4-AFB3-653F785EAFEE

Q27677060-5EBECE4E-E99A-41CE-8B12-0BDCFA435898

Q27677060-751056AD-F325-4FFD-BC7C-55BC598887C9

Q27677060-8812E40A-BF12-4624-8CBD-C0B780CCCB61

Q27677060-AB2BC90F-F2C1-4B6C-B6A9-225C11583599

Q27677060-CEF1AD5C-DD5D-4412-A703-3DE5856718B1

Q27677060-D7B56401-2C78-4944-8626-3034ADD33B24

Q27677060-F1B1854F-0B7C-484E-9CE2-62458BBC2637

Q27677060-FBB9D256-16EE-44BF-9E9D-675EC0B1FB12

P2860

Q27677060-00D156C4-263E-476C-AFDC-AF9F33A65D6A

Q27677060-04E5FB9B-C9D6-4B1E-A4C8-2357AF100F7E

Q27677060-0D65ACF7-AF41-4107-A525-5C1925AA9579

Q27677060-10094088-69D9-4B75-B566-0C75F58496A0

Q27677060-271FC09B-1BDC-45EE-BE1F-F9D3AB4E30DA

Q27677060-305D8C96-F84D-4A30-9015-4C87C4604C9B

Q27677060-3510E0F9-AFBA-4AD5-843D-98F6CD905CC7

Q27677060-3CFDD88D-2887-47BC-8075-42C262E64260

Q27677060-509724D1-9DF1-4CE2-AB84-B7C8DFB392AC

Q27677060-5494F8B8-7461-4DA5-BEA7-763154459DDA

P2888

Q27677060-0DC1CEDB-5DCF-4DCE-8851-7CD61B00DB85

P304

Q27677060-98486AAA-0B46-425C-A55F-5B7C342D2435

P31

Q27677060-DB53B6BC-6CE3-4CF6-8B4B-A9218E20C88B

P356

Q27677060-84437883-33A3-41EC-B727-D38C6A625122

P433

Q27677060-5B3D53B5-3EF8-4A36-910E-94DEF76C01FC

P478

Q27677060-2E017422-A042-4A0C-B44E-D4088C978CD7

P50

Q27677060-61EBFE86-B2F5-4E7B-81F0-4E6E8A926F24

Q27677060-A371DBAA-6DA7-45D0-ACCD-CF61BD23B54E

Q27677060-CA6269EE-9C4D-4FB6-A2DB-A4BF6493BEAD

P577

Q27677060-E435FA9C-FC49-4DAD-8A50-6753285F8F62

P5875

Q27677060-86810150-69D9-42F6-A91B-2EF4FE12AF2D

P6179

Q27677060-CCEE95C7-2D1F-44B9-92D2-74864CB5608B

P698

Q27677060-874EE186-A3DA-4307-9243-2E78114F6694

P921

Q27677060-835674B7-4B11-48F6-AEF8-3C00CEA02D61

Q27677060-DC416A8D-0215-4DF5-B51F-82F2C5ACEB68

P932

Q27677060-7F7B5CFA-1855-468F-8055-6B854A5B654A

P356

P1433

Nature Chemical Biology

P1476

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

@en

P2093

Barry L Stoddard

http://www.w3.org/2001/XMLSchema#string

Dan S Tawfik

http://www.w3.org/2001/XMLSchema#string

Haim Leader

http://www.w3.org/2001/XMLSchema#string

Jasmine L Gallaher

http://www.w3.org/2001/XMLSchema#string

Moshe Goldsmith

http://www.w3.org/2001/XMLSchema#string

Per Greisen

http://www.w3.org/2001/XMLSchema#string

Ryo Takeuchi

http://www.w3.org/2001/XMLSchema#string

Sagar D Khare

http://www.w3.org/2001/XMLSchema#string

Yacov Ashani

http://www.w3.org/2001/XMLSchema#string

Yakov Kipnis

http://www.w3.org/2001/XMLSchema#string

P2860

De novo computational design of retro-aldol enzymes

Native protein sequences are close to optimal for their structures

Processing of X-ray diffraction data collected in oscillation mode

Kemp elimination catalysts by computational enzyme design

Alteration of enzyme specificity by computational loop remodeling and design

Switching Catalysis from Hydrolysis to Perhydrolysis in Pseudomonas fluorescens Esterase ,

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity

Macromolecular TLS refinement in REFMAC at moderate resolutions

Rapid and efficient site-specific mutagenesis without phenotypic selection

P2888

P304

294-300

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NCHEMBIO.777

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

8

http://www.w3.org/2001/XMLSchema#string

P50

Joel L. Sussman

P577

2012-02-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221807160

http://www.w3.org/2001/XMLSchema#string

P6179

1017096229

http://www.w3.org/2001/XMLSchema#string

P698

22306579

http://www.w3.org/2001/XMLSchema#string

P921

organophosphate

P932

3957331

http://www.w3.org/2001/XMLSchema#string