Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
about
Cullin-RING ubiquitin ligases: global regulation and activation cyclesIdentification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytesThe p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancersA giant protease with potential to substitute for some functions of the proteasomeAlternatively spliced products CC3 and TC3 have opposing effects on apoptosisThe first N-terminal transmembrane helix of each subunit of the antigenic peptide transporter TAP is essential for independent tapasin bindingProteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligaseCK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signalingHepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activityBRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damageAkt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 functionCDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3pThe ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and compositionSubunit arrangement in the human 20S proteasomeBub1 regulates chromosome segregation in a kinetochore-independent mannerMammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathwayp53 mediates the negative regulation of MDM2 by orphan receptor TR3Newly identified pair of proteasomal subunits regulated reciprocally by interferon gammaER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly.26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survivalDisease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation stateThe RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteinsMuscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin IActivation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin EMolecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomesRequirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityGeneral transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic dosesA DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/MTargeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunizationDNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody inductionRegulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathwayCaveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cellsSelective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro
P2860
Q21203558-8531D47E-81FA-4689-84C0-6CFE2A920B0DQ21245310-29400189-B2C6-4905-8A1B-09F6425D0318Q21245703-D4CA2B79-A4EE-4F9D-BB64-0783600076FBQ21245741-90EA0C63-92C1-4AE2-8C56-C27593971805Q22001460-0A140AD9-CB73-47B6-9D1F-06E3E52BB7D0Q22010984-DBE34D7D-7501-4B75-9F55-62EE2E305433Q24296500-95898581-88BD-44BE-AB57-5A1B83379CAAQ24299749-9C9849A3-0182-4DBF-B276-B951F21D73C6Q24300048-22319279-0D7F-4925-8C4A-12189B1CAABCQ24300867-4CD56C1B-0BC4-4835-B9AB-0E6012EEF7CBQ24301487-C731394B-63D6-4CBA-9B21-DE1340F65C9DQ24304442-6CB26E03-FFBD-4400-B102-064EAE3455EAQ24308679-32226334-4582-49FF-8FE0-32073B4C0F84Q24311263-6D501122-77A0-4601-AC3C-329FB4164068Q24311953-C35F92DB-887D-4856-845C-E8539B3E75DDQ24316069-810B9A2A-DCDC-472F-B250-AD6D9D1F5C2DQ24318831-AD27DBC1-6563-4826-9AB7-5695B9B7FF8DQ24321873-8FA9B2EC-0749-477A-BE59-F88EC6354B2CQ24322943-13E88497-7C78-4A18-A258-E89B2DE4CB4CQ24533211-691E852D-A91B-4F07-8C19-536C49A5257AQ24535312-3A5507BE-700C-432A-B5EF-EE0867CF06BAQ24542503-45F496E2-2E0B-4F92-AF02-B7998E9966D2Q24544268-1DEF777D-7994-41C7-852E-F69B5FB00AC6Q24548387-84DA90B9-EDEB-4290-8CCF-D1E41557B4D7Q24550350-C06FD3A3-7D2C-42D0-B124-1B0B23959D44Q24554569-E9E7B77A-A9E9-4594-B5EC-8E9EEF7C5E82Q24558612-1808917B-3CFB-4A3F-8CDD-94C1A23D40DBQ24562111-26919F6C-FC27-4FE0-9BD9-A91B5643F2F6Q24562414-AA497F5C-F148-459F-8439-E62838256F44Q24564328-C1463987-8A47-49D9-A15E-9424DC9550DFQ24597762-A71D0C3B-1352-481F-8505-95E2C08A0905Q24599944-CB55BDF1-61F0-4C83-AEFE-DDEF1DC02116Q24643988-895BEF38-55F7-4573-8CF4-9C3966788056Q24645843-79BAF51F-6AC3-4F5C-AFED-A1A383600343Q24645905-F5CA11A3-E11C-48D0-843A-A2520A28FA02Q24670153-D1AD7FA9-4429-4396-8DB2-DDDF04750AC8Q24671114-08542658-6457-40D2-B3CB-2F57F7D7247FQ24672316-A373797F-ACB5-4399-ADDC-8E0A553E3BB9Q24672900-91CE3144-E787-4141-B61E-39224EAF864DQ24675778-CFAE8A85-BF9E-43CB-BA7C-9FC381B0B5A4
P2860
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
description
1994 nî lūn-bûn
@nan
1994 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@ast
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@en
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@nl
type
label
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@ast
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@en
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@nl
prefLabel
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@ast
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@en
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@nl
P2093
P3181
P1433
P1476
Inhibitors of the proteasome b ...... ented on MHC class I molecules
@en
P2093
A L Goldberg
L Rothstein
P304
P3181
P356
10.1016/S0092-8674(94)90462-6
P407
P577
1994-09-09T00:00:00Z