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The chemical biology of clinically tolerated NMDA receptor antagonists

The chemical biology of clinically tolerated NMDA receptor antagonists

http://www.wikidata.org/entity/Q28248958

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Fast, non-competitive and reversible inhibition of NMDA-activated currents by 2-BFI confers neuroprotection Memantine for schizophrenia Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease Novel NMDA receptor modulators: an update NMDA receptor modulators: an updated patent review (2013-2014)Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury Glutamate receptor ion channels: structure, regulation, and function Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease Antitussive effects of memantine in guinea pigs.Environmental exposure, obesity, and Parkinson's disease: lessons from fat and old worms.Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia.Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.New treatments for chronic prostatitis/chronic pelvic pain syndrome Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus.Memantine enhances recovery from stroke.Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies.Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives Protection from glutamate-induced excitotoxicity by memantine Encoding of the cough reflex in anesthetized guinea pigs.Pharmacologic amelioration of severe hypoglycemia-induced neuronal damage.The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats.Changes in D-aspartate ion currents in the Aplysia nervous system with aging Syntheses and pharmacological evaluations of novel N-substituted bicyclo-heptane-2-amines at N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subtype 3A promotes apoptosis in developing mouse brain exposed to hyperoxia.Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators Potential natural products for Alzheimer's disease: targeted search using the internal ribosome entry site of tau and amyloid-β precursor protein.Neurotoxicity by synthetic androgen steroids: oxidative stress, apoptosis, and neuropathology: A review.Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection?Extracellular proton-modulated pore-blocking effect of the anticonvulsant felbamate on NMDA channels Glutamate production by HIV-1 infected human macrophage is blocked by the inhibition of glutaminase Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders.The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention.Memantine for prevention of migraine: a retrospective study of 60 cases.Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.NMDA Neurotransmission Dysfunction in Behavioral and Psychological Symptoms of Alzheimer's Disease.Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis.Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry.

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P2860

The chemical biology of clinically tolerated NMDA receptor antagonists

http://www.wikidata.org/entity/Q28248958

description

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The chemical biology of clinically tolerated NMDA receptor antagonists

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The chemical biology of clinically tolerated NMDA receptor antagonists

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The chemical biology of clinically tolerated NMDA receptor antagonists

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The chemical biology of clinically tolerated NMDA receptor antagonists

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The chemical biology of clinically tolerated NMDA receptor antagonists

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J.1471-4159.2006.03991.X

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Journal of Neurochemistry

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The chemical biology of clinically tolerated NMDA receptor antagonists

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Huei-Sheng Vincent Chen

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Stuart A Lipton

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P2860

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

A synaptic model of memory: long-term potentiation in the hippocampus

Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

Magnesium gates glutamate-activated channels in mouse central neurones

Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation.

Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data.

Low affinity channel blocking (uncompetitive) NMDA receptor antagonists as therapeutic agents--toward an understanding of their favorable tolerability.

NMDA receptor subunits: diversity, development and disease.

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