Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders.
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HIV-associated neurocognitive disorder--pathogenesis and prospects for treatmentInhibition of microglia activation as a phenotypic assay in early drug discoveryHIV-1, methamphetamine and astrocytes at neuroinflammatory CrossroadsMitochondrial glutaminase release contributes to glutamate-mediated neurotoxicity during human immunodeficiency virus-1 infectionInterferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disordersTNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminaseSerial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegenerationGlutamate metabolism and HIV-associated neurocognitive disorders.Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disordersGlutaminase 1 is essential for the differentiation, proliferation, and survival of human neural progenitor cells.STAT1 regulates human glutaminase 1 promoter activity through multiple binding sites in HIV-1 infected macrophagesRole of the immune system in HIV-associated neuroinflammation and neurocognitive implications.Induction of Heme Oxygenase-1 Deficiency and Associated Glutamate-Mediated Neurotoxicity Is a Highly Conserved HIV Phenotype of Chronic Macrophage Infection That Is Resistant to Antiretroviral TherapyHIV-infected microglia mediate cathepsin B-induced neurotoxicity.Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity.Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation.HIV-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-AIDS.Targeting the glutamatergic system for the treatment of HIV-associated neurocognitive disordersRIG-I detects HIV-1 infection and mediates type I interferon response in human macrophages from patients with HIV-1-associated neurocognitive disorders.Proximal tubule-specific glutamine synthetase deletion alters basal and acidosis-stimulated ammonia metabolism.IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase.Disrupted cerebral metabolite levels and lower nadir CD4 + counts are linked to brain volume deficits in 210 HIV-infected patients on stable treatmentProtective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus EncephalomyelitisTryptophan Metabolism and Its Relationship with Depression and Cognitive Impairment Among HIV-infected Individuals.Effects of triptolide on hippocampal microglial cells and astrocytes in the APP/PS1 double transgenic mouse model of Alzheimer's disease.Novel treatment with neuroprotective and antiviral properties against a neuroinvasive human respiratory virus.Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND)Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4+ T Cells.N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain.Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory.Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice.Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate.Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869.
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P2860
Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Glutaminase dysregulation in H ...... ated neurocognitive disorders.
@ast
Glutaminase dysregulation in H ...... ated neurocognitive disorders.
@en
type
label
Glutaminase dysregulation in H ...... ated neurocognitive disorders.
@ast
Glutaminase dysregulation in H ...... ated neurocognitive disorders.
@en
prefLabel
Glutaminase dysregulation in H ...... ated neurocognitive disorders.
@ast
Glutaminase dysregulation in H ...... ated neurocognitive disorders.
@en
P2093
P2860
P1476
Glutaminase dysregulation in H ...... ated neurocognitive disorders.
@en
P2093
Beibei Jia
Jialin C Zheng
Lixia Zhao
Norman Curthoys
P2860
P304
15195-15204
P356
10.1523/JNEUROSCI.2051-11.2011
P407
P577
2011-10-01T00:00:00Z