GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions
about
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasionThe multifunctional GIT family of proteinsConsensus substrate sequence for protein-tyrosine phosphatase receptor type ZSrc and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.Identification of two tyrosine residues required for the intramolecular mechanism implicated in GIT1 activation.Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injuryInduction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.Peptide Bbeta(15-42) preserves endothelial barrier function in shock.Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.Calcium/Calmodulin-dependent protein kinase II delta 6 (CaMKIIdelta6) and RhoA involvement in thrombin-induced endothelial barrier dysfunction.Endothelial nitric-oxide synthase (eNOS) is activated through G-protein-coupled receptor kinase-interacting protein 1 (GIT1) tyrosine phosphorylation and Src proteinGPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone massG-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formationSpecific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function.Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection.GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillinEndothelial focal adhesions and barrier function.An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.Regulation of vascular permeability by sphingosine 1-phosphate.Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammationRho GTPases in platelet functionBarrier enhancing signals in pulmonary edema.Characterization of vascular permeability using a biomimetic microfluidic blood vessel model.Regulation of pulmonary endothelial barrier function by kinases.Loss of focal adhesion kinase enhances endothelial barrier function and increases focal adhesions.GIT1 is a scaffold for ERK1/2 activation in focal adhesions.Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins.Differentiated localizations of phosphorylated focal adhesion kinase in endothelial cells of rat splenic sinus.RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.Spatial intratumoural heterogeneity in the expression of GIT1 is associated with poor prognostic outcome in oestrogen receptor positive breast cancer patients with synchronous lymph node metastases.Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells
P2860
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P2860
GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@ast
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@en
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@nl
type
label
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@ast
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@en
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@nl
prefLabel
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@ast
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@en
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@nl
P2093
P50
P1433
P1476
GIT1 mediates thrombin signali ...... r of RhoA-type focal adhesions
@en
P2093
Geerten P van Nieuw Amerongen
Guoyong Yin
K Fujiwara
Kanchana Natarajan
Ryan J Hoefen
Victor W M van Hinsbergh
P304
P356
10.1161/01.RES.0000125627.77235.0C
P407
P577
2004-03-11T00:00:00Z