Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation
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CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substratesFKBP51 and FKBP52 in signaling and diseaseSubcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowthNuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin betaThe microtubule-associated protein doublecortin-like regulates the transport of the glucocorticoid receptor in neuronal progenitor cells.Brain distribution of carboxy terminus of Hsc70-interacting protein (CHIP) and its nuclear translocation in cultured cortical neurons following heat stress or oxygen-glucose deprivation.Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons.Management of cytoskeleton architecture by molecular chaperones and immunophilins.The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress.Back to your heart: ubiquitin proteasome system-regulated signal transductionFluorescent protein-labeled glucocorticoid receptor alpha isoform trafficking in cultured human trabecular meshwork cells.The pathology of cellular anti-stress mechanisms: a new frontier.ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complexCHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation.C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1.The role of ubiquitin ligases in cardiac disease.Turning off estrogen receptor beta-mediated transcription requires estrogen-dependent receptor proteolysis.Regulation of glucocorticoid receptor activity by a stress responsive transcriptional cofactor.S100A6 mediates nuclear translocation of Sgt1: a heat shock-regulated protein.The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events.The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells.Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor.Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore.The prospect of FKBP51 as a drug target.
P2860
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P2860
Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Retrograde transport of the gl ...... ry for proteasomal degradation
@ast
Retrograde transport of the gl ...... ry for proteasomal degradation
@en
Retrograde transport of the gl ...... ry for proteasomal degradation
@nl
type
label
Retrograde transport of the gl ...... ry for proteasomal degradation
@ast
Retrograde transport of the gl ...... ry for proteasomal degradation
@en
Retrograde transport of the gl ...... ry for proteasomal degradation
@nl
prefLabel
Retrograde transport of the gl ...... ry for proteasomal degradation
@ast
Retrograde transport of the gl ...... ry for proteasomal degradation
@en
Retrograde transport of the gl ...... ry for proteasomal degradation
@nl
P2093
P921
P1476
Retrograde transport of the gl ...... ry for proteasomal degradation
@en
P2093
Jennifer M Harrell
Paul R Housley
Stephen K Fisher
William B Pratt
P356
10.1016/J.MOLBRAINRES.2003.12.015
P407
P577
2004-04-07T00:00:00Z