The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells.
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Suppressive roles of calreticulin in prostate cancer growth and metastasisAnti-androgenic effects of flavonols in prostate cancerDevelopment and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells.FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells.Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/BakThe N-terminal domain of the androgen receptor drives its nuclear localization in castration-resistant prostate cancer cellsInhibition of glycogen synthase kinase-3β counteracts ligand-independent activity of the androgen receptor in castration resistant prostate cancer.High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.Novel drugs targeting the androgen receptor pathway in prostate cancer.CYP17A1 inhibitors in castration-resistant prostate cancerBerberine suppresses androgen receptor signaling in prostate cancer.17-ABAG, a novel geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition.Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression.Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expressionInhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in boneConstitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors.Advances in androgen receptor targeted therapy for prostate cancerHDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer.Signalling pathways in prostate carcinogenesis: potentials for molecular-targeted therapy.EAF2 regulates DNA repair through Ku70/Ku80 in the prostate.Horizon scanning for novel therapeutics for the treatment of prostate cancer.Androgen receptor co-activators in the regulation of cellular events in prostate cancer.Management of metastatic castration-resistant prostate cancer: recent advances.Targeting the androgen receptor in prostate cancer.Targeting heat shock proteins in metastatic castration-resistant prostate cancer.Hsp90, the concertmaster: tuning transcription.Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer CellsSecond-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35 xenograft prostate tumors to castration resistance.A novel HSP90 inhibitor delays castrate-resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis.Cytoplasmic localization of the androgen receptor is independent of calreticulin.Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity.N-terminal domain of the androgen receptor contains a region that can promote cytoplasmic localization.Perspectives on designs of antiandrogens for prostate cancer.Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90.Capillarisin blocks prostate-specific antigen expression on activation of androgen receptor in prostate carcinoma cells.NAD(P)H-quinone oxidoreductase 1 silencing aggravates hormone-induced prostatic hyperplasia in mice.Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia.A Novel Mechanism for Cross-Adaptation between Heat and Altitude Acclimation: The Role of Heat Shock Protein 90
P2860
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P2860
The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The Hsp90 inhibitor, 17-AAG, p ...... ractory prostate cancer cells.
@en
type
label
The Hsp90 inhibitor, 17-AAG, p ...... ractory prostate cancer cells.
@en
prefLabel
The Hsp90 inhibitor, 17-AAG, p ...... ractory prostate cancer cells.
@en
P2093
P2860
P356
P1433
P1476
The Hsp90 inhibitor, 17-AAG, p ...... ractory prostate cancer cells.
@en
P2093
Anthony J Saporita
P2860
P304
P356
10.1002/PROS.20541
P577
2007-04-01T00:00:00Z