Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery
about
Characterization of the Conus bullatus genome and its venom-duct transcriptome.Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme InactivationFrom Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide ToxinsA designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based libraryA novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptorsFrom molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypesSample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegataIn the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compoundsMolecular evolution and diversity of Conus peptide toxins, as revealed by gene structure and intron sequence analysesDietary breadth is positively correlated with venom complexity in cone snailsPhylogeny of the genus Turris: correlating molecular data with radular anatomy and shell morphologyThe Global Invertebrate Genomics Alliance (GIGA): developing community resources to study diverse invertebrate genomes.The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compoundsEvolution of Conus peptide genes: duplication and positive selection in the A-superfamilyConstraining cyclic peptides to mimic protein structure motifs.Tinnitus: network pathophysiology-network pharmacology.Comparison of the Venom Peptides and Their Expression in Closely Related Conus Species: Insights into Adaptive Post-speciation Evolution of Conus ExogenomesAlpha-conopeptides specifically expressed in the salivary gland of Conus pulicarius.Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatusRapid sensitive analysis of cysteine rich peptide venom components.Correlating molecular phylogeny with venom apparatus occurrence in Panamic auger snails (Terebridae)Accessing novel conoidean venoms: Biodiverse lumun-lumun marine communities, an untapped biological and toxinological resource.Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor.Marine microorganism-invertebrate assemblages: perspectives to solve the "supply problem" in the initial steps of drug discoveryCharacterization of conantokin Rl-A: molecular phylogeny as structure/function study.Natural products and ion channel pharmacologyGenome mining for ribosomally synthesized natural productsCupricyclins, novel redox-active metallopeptides based on conotoxins scaffold.A novel approach for in vivo screening of toxins using the Drosophila Giant Fiber circuit.Multicomponent venom of the spider Cupiennius salei: a bioanalytical investigation applying different strategies.Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct.Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs.Specialized insulin is used for chemical warfare by fish-hunting cone snails.ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca(v)2.2 ion channels.Conantokin-P, an unusual conantokin with a long disulfide loopNovel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome.Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor.High conopeptide diversity in Conus tribblei revealed through analysis of venom duct transcriptome using two high-throughput sequencing platformsCloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.
P2860
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P2860
Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@ast
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@en
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@nl
type
label
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@ast
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@en
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@nl
prefLabel
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@ast
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@en
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@nl
P3181
P356
P1476
Diversity of the neurotoxic Co ...... rted pharmacological discovery
@en
P2093
Baldomero M Olivera
Russell W Teichert
P304
P3181
P356
10.1124/MI.7.5.7
P407
P577
2007-10-01T00:00:00Z