LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells
about
PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasionGroup II p21-activated kinases as therapeutic targets in gastrointestinal cancerRegulators of Actin Dynamics in Gastrointestinal Tract TumorsApproaches of targeting Rho GTPases in cancer drug discoveryThe role of p21-activated kinases in hepatocellular carcinoma metastasisPAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesionSignaling, Regulation, and Specificity of the Type II p21-activated KinasesMicroRNA-433 inhibits cell proliferation in hepatocellular carcinoma by targeting p21 activated kinase (PAK4)Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitorsPAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesisp21-Activated kinase inhibitors: a patent reviewmicroRNA-126 suppresses PAK4 expression in ovarian cancer SKOV3 cellsp21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cellsPAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasisOncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesisTargeting Rho-GTPases in immune cell migration and inflammation.By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in gliomaA novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth.PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells.Recent advances in the development of p21-activated kinase inhibitorsP21 activated kinases: structure, regulation, and functions.Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma.Activated Pak4 expression correlates with poor prognosis in human gastric cancer patients.Oxymatrine targets EGFR(p-Tyr845) and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells.Differential role for PAK1 and PAK4 during the invadopodia lifecycle.Prognostic significance of PAK4 expression in gastric cancer.A Novel Pak1/ATF2/miR-132 Signaling Axis Is Involved in the Hematogenous Metastasis of Gastric Cancer Cells.PAK4-6 in cancer and neuronal development.PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathwaysThe pak4 protein kinase in breast cancer.Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma.p21-activated kinase 4: a druggable target in the elusive oncogenic KRAS pathway?Computational insight into p21-activated kinase 4 inhibition: a combined ligand- and structure-based approach.
P2860
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P2860
LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells
description
2012 nî lūn-bûn
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2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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name
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@ast
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@en
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@nl
type
label
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@ast
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@en
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@nl
prefLabel
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@ast
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@en
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@nl
P2093
P1433
P1476
LCH-7749944, a novel and poten ...... in human gastric cancer cells
@en
P2093
Dongmei Zhao
Huizhi Peng
Jian Zhang
Maosheng Cheng
Qiqiang Guo
P356
10.1016/J.CANLET.2011.11.007
P407
P577
2012-04-01T00:00:00Z