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Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine 4 2 Receptors: UNIQUE ROLE OF HALOGEN BONDING REVEALEDFirst-Principles Determination of Molecular Conformations of Indolizidine (-)-235B' in SolutionSynthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl)epibatidine analogues. Nicotinic partial agonists.Synthesis of phantasmidineStructural answers and persistent questions about how nicotinic receptors work.Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues of 2'-fluoro-3'-(4-nitrophenyl)deschloroepibatidine.Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and miceSynthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs.Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues.Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation3'-Fluoro substitution in the pyridine ring of epibatidine improves selectivity and efficacy for alpha4beta2 versus alpha3beta4 nAChRs.The 7-aza-norbornane nucleus of epibatidine: 7-aza-bicyclo-[2.2.1]heptan-7-ium chloride.Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: a computational and experimental study using epibatidine-related molecular probes.Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors.Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs.The enantiomers of epiboxidine and of two related analogs: Synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Epibatidine structure-activity relationships
@ast
Epibatidine structure-activity relationships
@en
Epibatidine structure-activity relationships
@nl
type
label
Epibatidine structure-activity relationships
@ast
Epibatidine structure-activity relationships
@en
Epibatidine structure-activity relationships
@nl
prefLabel
Epibatidine structure-activity relationships
@ast
Epibatidine structure-activity relationships
@en
Epibatidine structure-activity relationships
@nl
P1476
Epibatidine structure-activity relationships
@en
P2093
F Ivy Carroll
P304
P356
10.1016/J.BMCL.2004.02.007
P407
P577
2004-04-19T00:00:00Z