Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation
about
Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenulaThe α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats.Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms.Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001AT-1001 Is a Partial Agonist with High Affinity and Selectivity at Human and Rat α3β4 Nicotinic Cholinergic Receptors.High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice.Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula.Functional characterization of AT-1001, an α3β4 nicotinic acetylcholine receptor ligand, at human α3β4 and α4β2 nAChRMedial habenula output circuit mediated by α5 nicotinic receptor-expressing GABAergic neurons in the interpeduncular nucleusPhysical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors.Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors.Effects of soluble β-amyloid on the release of neurotransmitters from rat brain synaptosomes.A Simple Representation of Three-Dimensional Molecular Structure.Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors.Visible-Light-Mediated Two-Fold Unsymmetrical C(sp3 )-H Functionalization and Double C-F Substitution.
P2860
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P2860
Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Novel α3β4 nicotinic acetylcho ...... and pharmacological evaluation
@en
Novel α3β4 nicotinic acetylcho ...... nd pharmacological evaluation.
@nl
type
label
Novel α3β4 nicotinic acetylcho ...... and pharmacological evaluation
@en
Novel α3β4 nicotinic acetylcho ...... nd pharmacological evaluation.
@nl
prefLabel
Novel α3β4 nicotinic acetylcho ...... and pharmacological evaluation
@en
Novel α3β4 nicotinic acetylcho ...... nd pharmacological evaluation.
@nl
P2093
P2860
P356
P1476
Novel α3β4 nicotinic acetylcho ...... and pharmacological evaluation
@en
P2093
Cris Olsen
Faming Jiang
Lawrence Toll
Nurulain Zaveri
Willma Polgar
P2860
P304
P356
10.1021/JM1006148
P407
P577
2010-10-27T00:00:00Z