Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
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Current hypotheses on how microsatellite instability leads to enhanced survival of Lynch Syndrome patientsInteractions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer.MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instabilityWHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myelomaAssociation of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations.Molecular origins of cancer: Molecular basis of colorectal cancerMicrosatellite instability in colorectal cancerSomatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotypeSomatic mosaicism in the human genomePMS2 monoallelic mutation carriers: the known unknownClinical implications of BRAF mutation test in colorectal cancer.Opportunities for immunotherapy in microsatellite instable colorectal cancerThe biological complexity of colorectal cancer: insights into biomarkers for early detection and personalized careThe genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discoveryHereditary Syndromes Manifesting as Endometrial Carcinoma: How Can Pathological Features Aid Risk Assessment?The interaction of the human MutL homologues in hereditary nonpolyposis colon cancerA review of the clinical relevance of mismatch-repair deficiency in ovarian cancerDNA replication fidelity and cancerThe PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatinRealizing the promise of cancer predisposition genes.Microsatellite analysis of hereditary nonpolyposis colorectal cancer-associated colorectal adenomas by laser-assisted microdissection: correlation with mismatch repair protein expression provides new insights in early steps of tumorigenesisA procedure for the detection of linkage with high density SNP arrays in a large pedigree with colorectal cancer.Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families.Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management.An ATM homologue from Arabidopsis thaliana: complete genomic organisation and expression analysis.Genetic implications of double primary cancers of the colorectum and endometrium.Mouse models for colorectal cancer.Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions.Incomplete Segregation of MSH6 Frameshift Variants with Phenotype of Lynch Syndrome.The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedsideGenetic susceptibility to non-polyposis colorectal cancer.Suspected Lynch syndrome associated MSH6 variants: A functional assay to determine their pathogenicityClinical challenges in management of familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer.Genetic testing and counseling for hereditary forms of colorectal cancer.Prioritizing candidate disease genes by network-based boosting of genome-wide association data.Deficiency of a novel mismatch repair activity in a bladder tumor cell line.Tumour suppressor gene mutations in humans and mice: parallels and contrastsThe PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene.Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history.
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P2860
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@ast
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@en
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@nl
type
label
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@ast
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@en
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@nl
prefLabel
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@ast
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@en
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@nl
P2093
P2860
P3181
P356
P1433
P1476
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
@en
P2093
R Kikuchi-Yanoshita
P2860
P2888
P3181
P356
10.1038/NG1197-271
P407
P577
1997-11-01T00:00:00Z
P5875
P6179
1042080593