Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer.
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The interaction of DNA mismatch repair proteins with human exonuclease IHNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexesInteractions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphismsMutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female micehMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machineryLack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsSeparation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination.The interaction of the human MutL homologues in hereditary nonpolyposis colon cancerA human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2DNA mismatch repair and mutation avoidance pathwaysAdenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1Steady-state regulation of the human DNA mismatch repair system.Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSĪ±.Functional interactions and signaling properties of mammalian DNA mismatch repair proteins.Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair.A study of genomic instability in early preneoplastic colonic lesions.The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome.EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae.Functional analysis in mouse embryonic stem cells reveals wild-type activity for three MSH6 variants found in suspected Lynch syndrome patients.The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complexLoss of DNA mismatch repair function and cancer predisposition in the mouse: animal models for human hereditary nonpolyposis colorectal cancer.14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancerOligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants.Functional analysis helps to clarify the clinical importance of unclassified variants in DNA mismatch repair genes.Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding.Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functionsA novel deleterious c.2656G>T MSH2 germline mutation in a Pakistani family with a phenotypic overlap of hereditary breast and ovarian cancer and Lynch syndrome.DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets.Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future.Genomic instability and colon carcinogenesis: from the perspective of genes.Sequence analysis of the mismatch repair gene hMSH6 in the germline of patients with familial and sporadic colorectal cancer.Biochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA.Evolutionary origin, diversification and specialization of eukaryotic MutS homolog mismatch repair proteins.Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays.Assessing the pathogenicity of MLH1 missense mutations in patients with suspected hereditary nonpolyposis colorectal cancer: correlation with clinical, genetic and functional features.
P2860
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P2860
Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer.
description
1998 nĆ® lÅ«n-bĆ»n
@nan
1998 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕøÕµÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
Õ¤ÕøÖÕ”Õ®
@hyw
1998 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ¶ÕøÕµÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
1998幓ć®č«ę
@ja
1998幓č«ę
@yue
1998幓č«ę
@zh-hant
1998幓č«ę
@zh-hk
1998幓č«ę
@zh-mo
1998幓č«ę
@zh-tw
1998幓č®ŗę
@wuu
name
Interactions of human hMSH2 wi ...... nonpolyposis colorectal cancer
@nl
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@ast
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@en
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@en-gb
type
label
Interactions of human hMSH2 wi ...... nonpolyposis colorectal cancer
@nl
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@ast
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@en
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@en-gb
prefLabel
Interactions of human hMSH2 wi ...... nonpolyposis colorectal cancer
@nl
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@ast
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@en
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@en-gb
P2093
P2860
P3181
P356
P1476
Interactions of human hMSH2 wi ...... onpolyposis colorectal cancer.
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.18.11.6616
P407
P577
1998-11-01T00:00:00Z